Tuberculosis and the Tubercle Bacillus Editors:  Stewart T. Cole, Kathleen Davis Eisenach, David N. McMurray &       William R. Jacobs, Jr. Pages:  603   Hard Cover ISBN: 1555812325 ASM Press     2005 List Price:  $125.95 non-member  $115.95 member   Microbiology Titles                  Find New and Used Here Pulmonary Titles

From the Publisher:     

     The World Health Organization declared tuberculosis a global health emergency, and despite efforts toward eradication, the situation has intensified.  Social and operational factors, including the growing AIDS epidemic and increasing drug resistance, have dramatically compounded the tuberculosis crisis.  Tuberculosis and the Tubercle Bacillus, an extension of the 1994 publication Tuberculosis, is a state-of-the-art review of the corpus of knowledge available to researchers in the field.

     Divided into three comprehensive sections, this new volume begins with an examination of the current issues related to tuberculosis, including clinical and epidemiological features of the disease-causing strains.  Topics explored in the second section include genetics, genomics, cell structure, and metabolism of Mycobacterium tuberculosis.  Tuberculosis and the Tubercle Bacillus concludes with a detailed discussion of the host-bacillus relationship and presents information on animal models and their roles in prevention of tuberculosis.

Key Features

• Reviews state-of-the-art corpus of knowledge in this critical area of global health research
• Provides clinical and epidemiological features of the disease-causing strains of Mycobacterium tuberculosis.
• Explores the genetics, genomics, cell structure, and metabolism of M. tuberculosis
• Examines various animal models and their roles in vaccine development and testing
• Features contributors who are world leaders in the field of tuberculosis research

Table of Contents:

Introduction

I.  Historical Perspective

Chapter 1.     Global Burden of Tuberculosis:  Past, Present, and Future

II.  Clinical and Epidemiological Perspectives

Chapter 2.     Overview of Clinical Tuberculosis

Chapter 3.     Molecular Epidemiology of Mycobacterium tuberculosis

III.  Diagnostics

Chapter 4.     Clinical Mycobacteriology (Tuberculosis) Laboratory:  Services and Methods

Chapter 5.     Immune-Based Methods

Chapter 6.     Molecular Diagnosis of Mycobacterial Infections

IV.  Current Therapies and Drug Resistance

Chapter 7.     Global Impact of Multidrug Resistance

Chapter 8.     Mechanisms of Drug Resistance in Mycobacterium tuberculosis

V.  Genomics

Chapter 9.     Introduction to Functional Genomics of the Mycobacterium tuberculosis Complex

Chapter 10.   Comparative Genomics and Evolution of Mycobacterium bovis BCG

Chapter 11.   TB or Not TB:  A Structural Genomics Mission?

VI.  Genetics

Chapter 12.   Gene Replacement Systems

Chapter 13.   Repetitive DNA in the Mycobacterium tuberculosis Complex

Chapter 14.   Mycobacteriophages and Tuberculosis

Chapter 15.   Control of Mycobacterial Transcription

VII.  Cell Structure

Chapter 16.   The Proteome of Mycobacterium tuberculosis

Chapter 17.   The Cell Envelope of Mycobacterium tuberculosis with Special Reference to the Capsule and Outer Permeability Barrier

Chapter 18.   Structure, Biosynthesis, and Genetics of the Mycolic Acid-Arabinogalactan-Peptidoglycan Complex

Chapter 19.   A Waxy Tale, by Mycobacterium tuberculosis

VIII.  Metabolism

Chapter 20.   General Metabolism and Biochemical Pathways of Tubercule Bacilli

Chapter 21.   Iron Metabolism in the Tubercle Bacillus and Other Mycobacteria

Chapter 22.   Two-Component Systems, Protein Kinases, and Signal Transduction in Mycobacterium tuberculosis

Chapter 23.   Nucleic Acid Metabolism

Chapter 24.   Transport Processes

IX.  Host-Pathogen Interactions

Chapter 25.   Receptor-Mediated Recognition of Mycobacterium tuberculosis by Host Cells

Chapter 26.   Mycobacterium tuberculosis:  the Indigestible Microbe

Chapter 27.   Intracellular Models of Mycobacterium tuberculosis Infection

Chapter 28.   Dendritic Cells in Host Immunity to Mycobacterium tuberculosis Infection

X.  Host Immune Responses and Antigenic Variation

Chapter 29.   CD8 T Cells in Tuberculosis

Chapter 30.   CD1 and Tuberculosis

Chapter 31.   Th1 and Th2 Cytokines in the Human Immune Response to Tuberculosis

Chapter 32.   Role of Antibody-Mediated Immunity in Host Defense Against Mycobacterium tuberculosis

Chapter 33.   The PE and PPE Multigene Families of Mycobacteria

XI.  Animal Models

Chapter 34.   Mycobacterium marinarum and Fish and Frog Models of Infection

Chapter 35.   Experimental Infection Models of Tuberculosis in Domestic and Wild Animals

Chapter 36.   Animal Models of Tuberculosis

Chapter 37.   Tuberculosis Vaccine Preclinical Screening and Development

INDEX