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Description: One-third of the world’s human population is currently infected with tuberculosis. Tuberculosis remains epidemic, causing close to two million deaths each year. Most of these deaths occur in developing nations; however, developed nations also struggle with tuberculosis, contending with such growing challenges as drug resistance, immigration, immunosuppression, and nontuberculous mycobacterial infection. Nearly 30 years after the publication of the first edition, the Sixth Edition of this comprehensive reference gathers the most current science and tools available in the fight against tuberculosis, enabling readers to fully understand the underlying mechanisms of tuberculosis and correctly diagnose and manage the disease.
Tuberculosis and Nontuberculous Mycobacterial Infections is divided into three sections. Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant tuberculosis, vaccines, and tuberculosis in enclosed populations. Section II covers both classic and more recent clinical manifestations of tuberculosis infection. Separate chapters address every organ system as well as issues unique to pregnancy, infants and children, HIV infection, organ transplantation and immune reconstitution inflammatory syndrome. Section III explores nontuberculous mycobacterial infections, including a detailed discussion of the clinical syndromes produced by these organisms.
All the chapters have been written by leading experts whose experience ranges from basic and clinical research to bedside medicine.
New to the Sixth Edition This Sixth Edition features three new chapters: Tuberculosis in History; Tuberculosis and Organ Transplantation; and Mycobacterium bovis and Other Uncommon Members of the Mycobacterium tuberculosis Complex. The latest edition also examines the most recent epidemiologic and public health issues, including airline-associated infection, tuberculosis in the developing world, and the role of the World Health Organization and Departments of Public Health. All the chapters in the book have been thoroughly updated with the latest basic science, clinical manifestations, and diagnostic and therapeutic recommendations.
Key Features · Offers separate chapters exploring the effects of tuberculosis on each individual organ system · Examines the role and value of surgery in tuberculosis management · Sets forth the most current recommendations and practices for treating tuberculosis, including drug-resistant forms of the disease · Describes the latest preventive strategies, including vaccine development and treatment of latent tuberculosis
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Details the unique needs of special populations, including
infants and children, AIDS patients, and pregnant women
Table of Contents: I. General Considerations 1. Tuberculosis in History: Did It Change the Way We Live?, Thomas M. Daniel 2. Epidemiology and Host Factors, Asim K. Dutt 3. Pathophysiology and Immunology, Arthur M. Dannenberg 4. Laboratory Diagnosis and Susceptibility Testing, Gary W. Procop and Glenn D. Roberts 5. Diagnosis of Latent Tuberculosis Infection, Alfred A. Lardizabal and Lee B. Reichman 6. Treatment of Latent Tuberculosis Infection, Connie A. Haley 7. Chemotherapy of Tuberculosis, Thomas E. Dobbs and Risa M. Webb 8. Therapy of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, Barbara J. Seaworth and Robert N. Longfield 9. Role of Surgery in the Diagnosis and Management of Tuberculosis, Alan D. L. Sihoe and Wing Wai Yew 10. Bacillus Calmette-Guérin and New Vaccines against Tuberculosis, Timothy Lahey and C. Fordham von Reyn 11. Tuberculosis—a World Health Organization Perspective, Marcos A. Espinal and Mario C. Raviglione 12. Tuberculosis in Enclosed Populations, Sorana Segal-Maurer 13. Role of the Health Department—Legal and Public Health Considerations, Melisa Thombley, Kashef Ijaz, Beverly Metchock, and Philip LoBue
II. Clinical Syndromes 14. Pulmonary Tuberculosis, Mary E. Kreider and Milton D. Rossman 15. Upper Respiratory Tract Tuberculosis, Surinder K. Jindal and Ritesh Agarwal 16. Tuberculous Otomastoiditis, George A. Pankey 17. Ocular Tuberculosis, Daniel M. Albert, Robert J. Peralta, and Matthew J. Thompson 18. Central Nervous System Tuberculosis, John M. Leonard 19. Tuberculous Lymphadenitis and Parotitis, W. Garrett Hunt 20. Urogenital Tuberculosis, André A. Figueiredo, Antônio M. Lucon, and Miguel Srougi 21. Musculoskeletal Tuberculosis, Michael K. Leonard and Henry M. Blumberg 22. Cardiovascular Tuberculosis, John A. Crocco 23. Gastrointestinal Tuberculosis, Walter J. Coyle and Eric H. Choi 24. Tuberculous Peritonitis, Urvashi Vaid and Gregory C. Kane 25. Tuberculosis of the Liver, Biliary Tract, and Pancreas, Thomas H. Taylor, Dalia Ibrahim, and James H. Lewis 26. Cutaneous Tuberculosis, Michael K. Hill and Charles V. Sanders 27. Miliary Tuberculosis, Surendra K. Sharma and Alladi Mohan 28. Endocrine and Metabolic Aspects of Tuberculosis, Emily A. Blumberg and Christopher Vinnard 29. Hematologic Complications of Tuberculosis, Randall A. Oyer and David Schlossberg 30. Tuberculosis in Infants and Children, Jeffrey R. Starke 31. Pregnancy: Maternal, Fetal, and Neonatal Considerations, David M. Fleece and Stephen C. Aronoff 32. Tuberculosis Associated with HIV Infection, Midori Kato-Maeda, Annie Luetkemeyer and Peter M. Small 33. Tuberculosis and Organ Transplantation, José M. Aguado and Nina Singh 34. Paradoxical Reactions and the Immune Reconstitution Inflammatory Syndrome, Preston Church and Marc A. Judson
III. Nontuberculous Mycobacteria 35. Nontuberculous Mycobacteria: an Introduction, Henry Yeager 36. Mycobacterium avium Complex Disease, Jason E. Stout and Carol D. Hamilton 37. Rapidly Growing Mycobacteria, Barbara A. Brown-Elliott and Richard J. Wallace, Jr. 38. Mycobacterium kansasii, James C. Johnston and Kevin Elwood 39. Mycobacterium marinum, Emmanuelle Cambau and Alexandra Aubry 40. Mycobacterium scrofulaceum, Edward A. Horowitz 41. Mycobacterium bovis and Other Uncommon Members of the Mycobacterium tuberculosis Complex, Jaime Esteban and Noelia Alonso-Rodriguez 42. Other Nontuberculous Mycobacteria, Marvin J. Bittner and Laurel C. Preheim
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