Table of Contents:

Part One:  Introduction

Chapter 1.     Overview of Airway Mucus Clearance

Chapter 2.     The Biophysical Properties of Mucus

Chapter 3.     Regulation of Airway Mucus Secretion

Chapter 4.     Outcomes for Trials of Mucoactive Therapy

Chapter 5.     Adherence with the Use of Clearance Techniques  

Part Two:  Mucoactive Medications

Chapter 6.     Taxonomy of Mucoactive Medications

Chapter 7.     Mucoactive Drug Delivery

Chapter 8.     Expectorants

Chapter 9.     Mucolytics and Mucus Clearance

Chapter 10.   Modulation of Mucociliary Function by Drugs and Other Agents

Chapter 11.   Mucokinetic Agents and Surfactant

Chapter 12.   Mucoregulatory Medications

Chapter 13.   Hyperosmolar Solutions and Ion Channel Modifiers

Chapter 14.   Mucoactive Agents and the Upper Airway

Chapter 15.   Issues on Regulatory Approval of Mucoactive Drugs

Part Three:  Physical Therapy and Clearance Devices

Chapter 16.   Airway-Clearance Techniques Individually Tailored to Each Patient

Chapter 17.   High-Frequency Oscillation, PEP, and Flutter

Chapter 18.   Pediatric Mucus Clearance by Chest Physiotherapy:  Principles and Practice

Chapter 19.   Postoperative Mucus Clearance

Chapter 20.   Management of Airway Secretions in Patients with Severe Respiratory Muscle Dysfunction