The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain.
* Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields
Table of Contents:
Contributors
Preface
Monoamine Transporters: Vulnerable and
Vital Doorkeepers
i. Introduction
ii. Clinical Benefits: Demonstration of the Medical
Roles of Monoamine Transporters
iii. Preclinical Indications- Behavioral
Pharmacology
iv. Molecular Study: cDNA Cloning and Structure
Activity Relationship
v. Protein Regulations
vi. Animal Genetics
vii. The Transporter Genes as Risk Factors
viii. Perspectives for Medication Development
References
Therapeutic Targets in Alzheimer's
Disease and Related Tauopathies
i. Introduction to the Disease
ii. Attempts at Abeta Therapy
iii. Tau Hypothesis
iv. Tau Therapeutic Targets
v. Concluding Remarks
References
Therapeutic Targets for
Neuroprotection and/or Enhancement of Functional
Recovery Following Traumatic Brain Injury
i. Introduction
ii. Primary Injury Models
iii. Receptor-Based Targets for Neuroprotection
iv. Targeting Enzymatic Activity for Neuroprotection
v. Other Promising Strategies
vi. Future Directions for Optimization for Treatment
Regimens
References
Insulin, Synaptic Function, and
Opportunities for Neuroprotection
i. Introduction
ii. Insulin Within the Central Nervous System
iii. Insulin Receptors Within the Brain
iv. Insulin Signaling and Synaptic Function
v. Therapeutic Opportunities: Insulin and
Neuroprotection
vi. General Summary
References
Molecular Alterations in
Glioblastoma: Potential Targets for Immunotherapy
i. Introduction
ii. Genetic Alterations in Glioblastoma
iii. Ags and Biomarkers in Glioblastoma
iv. Ag-Specific Immunotherapy for Glioblastoma
v. Biomarker-Specific Chemotherapy for Gioblastoma
vi. Cytokine-Based Immunotherapy for Glioblastoma
vii. Chemoimmunotherapy for Gioblastoma
viii. Tumor-Associated Molecules Influencing
Glioblastoma
Immunotherapy
ix. Conclusions
References
Molecular Signaling and
Translational Significance of the Corticotropin
Releasing Factor System
i. Introduction to the Corticotropin Releasing
Factor Peptide Family
ii. Neural CRF Distribution
iii. CRF Binding and Signal Transduction
iv. Genes and Gene Systems Activated by CRF
v. Interactions with Other Neural Circuits
vi. Translational Significance of CRF
vii. Integrated CRF Function
References
Molecular Targets of Alcohol Action:
Translational Research for Pharmacotherapy
Development and Screening
i. Introduction
ii. Alcohol abuse and Dependence, Significance, and
Treatment Needs
iii. Preclinical Strategies for Identification of
Novel Targets of Alcohol Action
iv. Translational Strategies and Need for Continued
Biomarkers Development
References
Brain Nicotinic Receptors as
Emerging Targets for Drug Addiction: Neurobiology to
Translational Research
i. Introduction
ii. Brain nAChRs in Nicotine Addiction
iii. Brain NAChRs in Alcohol Dependence
iv. Brain nAChRs in Other Addictive Disorders
v. Limitations in nAChr-Based Translational Research
vi. Conclusions and Future Perspectives
References
Glutamatergic Neuroplasticity in
Cocaine Addiction
i. Introduction
ii. Neurocircuitry of Addiction
iii. Adaptations in Synaptic Plasticity
iv. Glutamate Homeostasis Hypothesis of Cocaine
Addiction
v. Redox Regulation of Neurons
vi. Promise for Glutamate-Mediated Pharmacotherapies
for Addiction
vii. Conclusion
References
Role of the Serotonergic System in
Alcohol Dependence: From Animal Models to Clinics
i. Introduction
ii. The Role of 5-HTT in Alcohol-Directed
Neuroadaptation, Intoxication Response, and
Potential for Abuse and Dependence
iii. Serotonergic Receptors: Molecular,
Pharmacological, and Physiological Aspects and Their
Role in Alcohol Dependence
iv. Interactions Between the Serotonergic System and
Other Neurotransmitter Systems in the Modulation of
Alcohol Consumption
v. Serotonergic System as a Potential Therapeutic
Target in Alcohol Dependence/Addiction
vi. Conclusions
References
Index.
