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From the Publisher:
The Bacterial Chromosome is a state-of-the art examination of the mechanisms governing genetic inheritance, a timely update to the 1990 publication of the same name. Advances in evolutionary theory have been stimulated by the availability of complete bacterial sequences, while recent biochemical research has revealed how protein machines control chromosome function.
Incorporating section overviews provided by eminent geneticists and biochemists, the book provides a link between classical experiments in chromosome physiology and new developments in genetic research. From the first section, "Genetic and Physical Structure," to the last, "Nonhomologous Recombination," The Bacterial Chromosome comprehensively covers the fundamental systems required for all bacterial cells to replicate chromosomes and organize genetic information. Complex biochemical reactions, including DNA replication, genetic recombination, and RNA transcription, are presented from both genetic and physical perspectives. The implications of the DNA sequence database are incorporated with information on horizontal gene transfer and the impact of phage genes on bacterial genomes.
Key Features
- Covers the fundamental systems that are required for all bacterial cells to replicate chromosomes and organize and utilize genetic information
- Provides a link between classical experiments in chromosome physiology and new developments in genetic research
- Includes and interprets structural information from recent X-ray crystal studies in a format that is logical for broad understanding of the biochemical process
- Presents complex biochemical reactions such as DNA replication and RNA transcription from both genetic and physical perspectives
- Incorporates section overviews written by eminent scientists in the fields of genetic and biochemical research
Table of Contents:
I. Genetic and Physical Structure
Chapter 1. Where's the Beef? Looking for Information in Bacterial Chromosomes
Chapter 2. The Dynamic Bacterial Genome
Chapter 3. Bacteriophages and the Bacterial Genome
Chapter 4. Global Approaches to the Bacterial Cell as an Integrated System
Chapter 5. Major Nucleoid Proteins in the Structure and Function of the Escherichia coli Chromosome
Chapter 6. Domain Behavior and Supercoil Dynamics in Bacterial Chromosomes
Chapter 7. Stationary-Phase Chromosomes
II. Replication Machines
Chapter 8. Replication Hits
Chapter 9. Initiation of Chromosomal Replication
Chapter 10. DNA Elongation
Chapter 11. SeqA Protein Binding and the Escherichia coli Replication Fork
Chapter 12. Reinitiation of DNA Replication
Chapter 13. The Terminus Region of the Escherichia coli Chromosome, or, All's Well That Ends Well.
III. Transcription Machines
Chapter 14. Overview of Transcription
Chapter 15. The Structure of Bacterial RNA Polymerase
Chapter 16. How Transcription Initiation Can Be Regulated in Bacteria
Chapter 17. Control of Transcription Termination and Antitermination
Chapter 18. mRNA Decay and Processing
IV. Homologous Recombination-Repair Machines
Chapter 19. Overview of Homologous Recombination and Repair Machines
Chapter 20. The RecA Protein
Chapter 21. Homologous Recombination by the RecBCD and RecF Pathways
Chapter 22. Recombination Machinery: Holliday Junction-Resolving Enzymes
Chapter 23. Dr. Jekyll and Mr. Hyde: How the MutSLH Repair System Kills the Cell
Chapter 24. Excision Repair and Bypass
Chapter 25. Misalignment-Mediated Mutations and Genetic Rearrangements at Repetitive DNA Sequences
V. Nonhomologous Recombinations
Chapter 26. DNA Transposons: Different Proteins and Mechanisms but Similar Rearrangements
Chapter 27. Potential Mechanisms for Linking Phage Mu Transposition with Cell Physiology
Chapter 28. Chromosome Dimer Resolution
Chapter 29. Replication of Bacterial Chromosomes: No Longer Going Around in Circles
INDEX
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