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From the Publisher:
More than 80 human diseases are attributable to autoimmunity, and one or another affect some seven percent of the population. Included are serious and life-threatening disorders like lupus, rheumatoid arthritis, insulin dependent diabetes and multiple sclerosis. Since such diseases are quite different in their clinical presentation, it has been common in the past to consider each individually. From the first edition in 1985 this book has been foremost in considering all of the autoimmune diseases collectively, emphasizing their traits in common as well as their individual differences. Since that time, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates a decade of new material; combines genetic themes applicable to inductive and effector mechanisms; surveys emerging therapies that relate generally to the autoimmune disorders; and discusses the biological basis of disease at genetic, molecular, cellular, and environmental levels.
NEW TO THIS EDITION:
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Extended discussion of autoimmunity from genes, cells and environment to experimental models and human populations
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Concise summaries of clinical features, diagnostic methods and current treatments for over 80 autoimmune and allied diseases
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Predictive strategies for forecasting and early recognition of autoimmune diseases
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Novel interventions to reverse progression of autoimmune disease
This book is an essential resource for basic and clinical scientists committed to the study of autoimmune diseases or the care of patients with such disorders.
Table of Contents:
Section I: Immunologic Basis of Autoimmunity
Chapter 1. Autoimmunity: A History of the Early Struggle for Recognition
Chapter 2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity
Chapter 3. General Features of Autoimmune Diseases
Chapter 4. Antigen Presentation, Dendritic Cells, and Autoimmunity
Chapter 5. Major Histocompatibility Complex and Autoimmunity
Chapter 6. T Cells and Autoimmunity
Chapter 7. Role of Th1 and Th2 Cells in Autoimmunity
Chapter 8. Tolerance and Autoimmunity: T Cells
Chapter 9. Regulatory T Cells
Chapter 10. Peptide-Based Instruction of Suppressor Commitment in Naive T Cells
Chapter 11. B Cells and Autoimmunity
Chapter 12. Memory B Cell Development
Chapter 13. Tolerance and Autoimmunity: B Cells
Chapter 14. Generation of T-Cell Antigenic Determinants in Autoimmunity and their Recognition
Chapter 15. Apoptotic Cells as a Source of Autoantigens
Chapter 16. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes
Chapter 17. Functional Effects of Autoantibodies
Chapter 18. Adhesion Molecules and Chemoattractants in the Pathogenesis and Treatment of Autoimmune Diseases
Chapter 19. Signaling Pathways in T and B Lymphocytes
Chapter 20. Genetics and Autoimmunity: HLA and MHC Genes
Chapter 21. Genetics and Autoimmunity: Non-MHC Genes
Chapter 22. Infections, Immunity, and Autoimmunity
Chapter 23. Noninfectious Environmental Agents and Autoimmunity
Chapter 24. Vaccines and Autoimmunity
Chapter 25. Sex, Pregnancy, and Autoimmunity
Chapter 26. Animal Models of Autoimmune Disease
Section II: Autoimmune Diseases
Multisystem Diseases
Chapter 27. Systemic Lupus Erythematosus and Related Diseases: Clinical Features
Chapter 28. Systemic Lupus Erythematosus: Immunologic Features
Chapter 29. Systemic Sclerosis, Scleroderma
Chapter 30. Antiphospholipid Syndrome
Chapter 31. Sjogren Syndrome
Chapter 32. Rheumatoid Arthritis
Chapter 33. Spondyloarthritis and Chronic Idiopathic Arhropathies
Chapter 34. Polymyositis and Dermatomyositis
Endocrine and Related Diseases
Chapter 35. Thyroid Disease
Chapter 36. Type I Diabetes
Chapter 37. Adrenalitis
Chapter 38. Polyendocrine Syndromes
Chapter 39. Gastritis and Pernicious Anemia
Chapter 40. Hypophysitis
Blood Diseases
Chapter 41. Hemolytic Anemia
Chapter 42. Thrombocytopenic Purpura
Chapter 43. Neutropenia
Chapter 44. Aplastic Anemia
Chapter 45. Clotting Disorders
Neurologic Diseases
Chapter 46. Multiple Sclerosis
Chapter 47. Peripheral Neuropathy
Chapter 48. Myasthenia Gravis and other Antibody-Associated Neurological Diseases
Chapter 49. Ocular Disease
Chapter 50. Inner Ear Disease
Intestinal, Hepatic, and Pancreatic Diseases
Chapter 51. Celiac Disease
Chapter 52. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn's Disease
Chapter 53. Chronic Hepatitis
Chapter 54. Primary Biliary Cirrhosis
Chapter 55. Primary Sclerosing Cholangitis
Chapter 56. Pancreatitis
Cutaneous Diseases
Chapter 57. Bullous Skin Diseases: Pemphigus and Pemphigold
Chapter 58. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria
Urogenital Diseases
Chapter 59. Kidney Disease: GoodPasture's Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis
Chapter 60. Orchitis and Male Infertility
Chapter 61. Oophoritis
Cardiovascular and Pulmonary Diseases
Chapter 62. Rheumatic Heart Disease
Chapter 63. Myocarditis and Dilated Cardiomyopathy
Chapter 64. Atherosclerosis: Autoimmunity to Heat-Shock Proteins
Chapter 65. Necrotizing Arteritis and Small Vessel Vasculitis
Chapter 66. Large and Medium Vessel Vasculitides
Chapter 67. Idiopathic Bronchiolitis Obliteran, Idiopathic Pulmonary Fibrosis, and Autoimmune Disorders of the Lung
Neoplasia and Autoimmunity
Chapter 68. Paraneoplastic Neurologic Diseases: Autoimmune Responses to Tumor Antigens
Chapter 69. Lymphoma and Autoimmune Disease
Chapter 70. Apoptosis and Autoimmunity: Lymphoproliferative Syndromes
Miscellaneous
Chapter 71. Cameos
Section III: Diagnosis, Prevention, and Therapy
Chapter 72. Autoantibody Assays, Testing, and Standardization
Chapter 73. T Cell Assays
Chapter 74. Prediction of Autoimmune Disease
Chapter 75. Prevention of Autoimmune Disease: Type I Diabetes as a Paradigm
Chapter 76. Emerging Therapies for Autoimmune Diseases
Section IV: Epilogue
Chapter 77. Advocatus Diaboli: What is not known about Autoimmune Disease
INDEX
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