Structural Biology of Bacterial Pathogenesis Editors:  Gabriel Waksman, Michael Caparon & Scott Hultgren Pages:  326   Hard Cover ISBN: 1555813011 ASM Press     2005 List Price:  $115.95 non-member  $105.95 member   Microbiology Titles                  Find New and Used Here

From the Publisher:     

     Recent technological advances have led to an outpouring of knowledge in the field of structural biology, yielding an abundance of informational resources available to researchers in the study of bacterial pathogenesis.  Structural Biology of Bacterial Pathogenesis explores recent developments in the understanding of the molecular basis of bacterial infectious diseases, from structures involved in adhesion and host recognition to those describing elements of bacterial secretion systems.  The first compilation of its kind, this new volume offers a convenient review of current research that will engage instructors, students, and professionals in the fields of bacterial pathogenesis and infectious diseases.

Replete with unique illustrations and written by experts, Structural Biology of Bacterial Pathogenesis provides a foundation for understanding the molecular interactions required for infection to occur.  Readers will gain insight into the role structures play both in our comprehension of pathological processes and in the design of novel antibiotic compounds.  Chapters address diverse topics, including host receptors of bacterial origin, sortase pathways in gram-positive bacteria, and bacterial secretion machinery.  Illustrations emphasize general concepts related to each disease profiled, as well as concepts concerning the infectious agent causing it.

Key Features:

• Compiles engaging, convenient reviews of current research
• Presents high-quality illustrations of key importance to structural biology
• Reviews comprehensively the molecular basis of bacterial pathogenesis
• Provides a link between pathology and its underlying molecular mechanisms
• Contributors are leading scientists in the fields of structural biology and bacterial infectious diseases

Table of Contents:

Chapter 1.     Regulation of Transcription by Anti-σ Factors

Chapter 2.     Two-Component Signal Transduction and Chemotaxis

Chapter 3.     Sugar Recognition and Bacterial Attachment

Chapter 4.     Host Receptors of Bacterial Origin

Chapter 5.     The Chaperone-Usher Pathway of Pilus Fiber Biogenesis

Chapter 6.     Structure and Assembly of Type IV Pilins

Chapter 7.     Sortase Pathways in Gram-Positive Bacteria

Chapter 8.     Structural Determinants of Haemophilus influenzae Adherence to Host Epithelia:  Variations on Type V Secretion

Chapter 9.     Type III Secretion Machinery and Effectors

Chapter 10.   Type IV Secretion Machinery

Chapter 11.   Injectosomes in Gram-Positive Bacteria

Chapter 12.   Toll/Interleukin-1 Receptors and Innate Immunity

INDEX