Table of Contents:

Part 1:  The Structure and Function of the Normal Pulmonary Circulation

Chapter 1.     Pulmonary Vascular Function

Chapter 2.     Functional Anatomy of the Pulmonary Microcirculation

Part 2:  Pathophysiology and Pathology of Pulmonary Vascular Disease

Chapter 3.     Pathology of Pulmonary Vascular Disease

Chapter 4.     Hypoxic Pulmonary Vasoconstriction and Hypertension

Chapter 5.     Pulmonary Vascular Remodeling

Chapter 6.     The Genetics of Pulmonary Hypertension

Part 3:  The Diagnosis of Pulmonary Hypertension

Chapter 7.     Clinical Features

Chapter 8.     Echocardiography

Chapter 9.     Imaging

Chapter 10.   Cardiac Catheterization of Patients with Pulmonary Hypertension

Chapter 11.   An Integrated Approach to the Diagnosis of Pulmonary Hypertension

Part 4:  Disorders Associated with Pulmonary Hypertension:  Pathobiology, Diagnosis and Treatment

Chapter 12.   Classification and Clinical Features of PHT

Chapter 13.   Pulmonary Arterial Hypertension

          13A.  Pathobiology of Pulmonary Arterial Hypertension
          13B.  Primary Pulmonary Hypertension:  Pathophysiological and Clinical Aspects
          13C.  Familial Primary Pulmonary Hypertension
          13D.  Pulmonary Hypertension Associated with Connective Tissue Disease
          13E.  Pulmonary Hypertension Related to Appetite Suppressants
          13F.  Pulmonary Hypertension Associated with Portal Hypertension
          13G.  Pulmonary Hypertension Related to HIV Infection
          13H.  Pulmonary Hypertension in Association with Congenital Systemic-to-Pulmonary Shunts
          13I.   Pulmonary Vasculitis
          13J.  Pulmonary Hypertension in Sickle Cell Disease and Thalassemia
          13K.  Conventional Medical Therapies
          13L.  Intravenous Prostacyclin for Pulmonary Arterial Hypertension
          13M.  Inhaled iloprost
          13N.  Oral and Subcutaneous Prostacyclin Analogs
          13O.  Inhaled Nitric Oxide
          13P.  Endothelin Receptor Antagonists
          13Q.  Novel Medical Approaches - Growth Inhibitors
          13R.  Lung Transplantation
          13S.  Atrial Septostomy
          13T.  An Integrated Approach to the Treatment of Pulmonary Arterial Hypertension

Chapter 14.   Pulmonary Venous Hypertension

          14A.  Diagnosis and Treatment of Left Heart Disease
          14B.  Pulmonary Veno-Occlusive Disease
          14C.  Pulmonary Capillary Hemangiomatosis

Chapter 15.   Pulmonary Hypertension Associated with Disorders of the Respiratory System and/or Hypoxemia

          15A.  Pulmonary Hypertension Due to Chronic Hypoxic Lung Disease
          15B.  Pulmonary Circulation in Obstructive Sleep Apnea
          15C.  An Integrated Approach to the Treatment of Pulmonary Hypertension due to Hypoxic Lung Disease

Part 5:  Pulmonary Thromboembolism and Pulmonary Vascular Tumors

Chapter 16.   Acute Pulmonary Thromboembolism

          16A.  Diagnosis
          16B.  Treatment

Chapter 17.   Chronic Thromboembolic Pulmonary Hypertension

Chapter 18.   Pulmonary Vascular Tumors

Part 6:  Pulmonary Hypertension in Pediatrics

Chapter 19.   Primary Pulmonary Hypertension in Children

Chapter 20.   Persistent Pulmonary Hypertension of the Newborn:  Strategies in Clinical Management

Part 7:  Pulmonary Circulation in Critical Care

Chapter 21.   Effects of Mechanical Ventilation on the Pulmonary Circulation

Chapter 22.   Effects of Lung Injury on the Pulmonary Circulation

Chapter 23.   Pharmacological Management of the Pulmonary Circulation in Critically Ill Patients

Part 8:  Pulmonary Circulation in Special Environments

Chapter 24.   High Altitude Pulmonary Edema and the Pulmonary Circulation

Chapter 25.   The Pulmonary Circulation in the Underwater Environment

Chapter 26.   The Fetal Lung Circulation

Part 9:  Disorders Causing Intrapulmonary Shunt

Chapter 27.   Hepatopulmonary Syndrome

Chapter 28.   Pulmonary Arteriovenous Malformations