Table of Contents:

Part One:  The Application of Clinical Assessment to the Drug Development Process

Chapter 1.     Providing Evidence of Therapeutic Benefit in Clinical Drug Development   

Part Two:  Measuring Outcomes

Chapter 2.     Use of Expiratory Airflows and Lung Volumes to Assess Outcomes in COPD

Chapter 3.     Exercise Testing

Chapter 4.     Sleep-Related Breathing Disturbances in COPD

Chapter 5.     Airway and Alveolar Determinants of Airflow Limitation in COPD

Chapter 6.     Gas Exchange

Chapter 7.     Genetics of COPD

Chapter 8.     Dyspnea

Chapter 9.     Exacerbations of COPD

Chapter 10.   Health Status Measurement in COPD

Chapter 11.   Health Resource Utilization

Part Three:  Specific Therapy

Chapter 12.   Anticholinergics

Chapter 13.   β-Adrenergic Receptor Agonist Bronchodilators in the Treatment of COPD

Chapter 14.   Theophylline and Phosphodiesterase Inhibitors in COPD

Chapter 15.   Corticosteroids in COPD

Chapter 16.   Antioxidants and Protease Inhibitors

Chapter 17.   An Integrated Approach to the Pharmacological Therapy of COPD