Table of Contents:

Part I

Chapter 1.     Challenges for the Vaccine Developer, Including Correlates of Protection

Part II:  Vaccination and Immune Response

Chapter 2.     Shaping Adaptive Immunity Against Pathogens:  The Contribution of Innate Immune Responses

Chapter 3.    Adjuvant-Induced Th2- and Th1- Dominated Immune Responses in Vaccination

Chapter 4.   Memory

Chapter 5.   T Cell-Based Vaccines

Part III:  Adjuvants

Chapter 6.   Microbial Adjuvants

Chapter 7.   Host-Derived Adjuvants

Chapter 8.   Microparticles as Vaccine Adjuvants and Delivery Systems

Chapter 9.   Liposomes and ISCOMs

Chapter 10.   Virosomal Technology and Mucosal Adjuvants

Part IV:  Classical and Novel Vaccination Strategies:  A Comparison

Chapter 11.   Classical Bacterial Vaccines

Chapter 12.   Subunit Vaccines and Toxoids

Chapter 13.   Engineering Virus Vectors for Subunit Vaccines

Chapter 14.   Update on Antiviral DNA Vaccine Research (2000-2003)

Chapter 15.   Live Recombinant Bacterial Vaccines

Chapter 16.   Mucosal Vaccination

Chapter 17.   Passive Vaccination and Antidotes:  A Novel Strategy for Generation of Wide Spectrum Protective Antibodies

Chapter 18.   Plant-Based Oral Vaccines

Chapter 19.   Virus-Like Particles:  Combining Innate and Adaptive Immunity for Effective Vaccination

Part V:  Vaccines for Specific Targets

Chapter 20.   Helicobacter pylori

Chapter 21.   Novel Vaccination Strategies Against Tuberculosis

Chapter 22.   Rationale for Malaria Vaccine Development

Chapter 23.   Vaccine for Specific Targets:  HIV

Chapter 24.   Vaccines Against Bioterror Agents

Part VI:  Vaccines in the Real World:  Safety, Cost Efficiency and Impact of Vaccination

Chapter 25.   Imperfect Vaccines and the Evolution of Pathogen Virulence

Chapter 26.   Cost-Effectiveness of Vaccinations

Chapter 27.   Immunological Safety of Vaccines:  Facts, Hypotheses and Allegations