From the Publisher:     

     Completely revised, the 4th Edition of this authoritative reference delivers a wealth of new information that enables readers to identify, treat, and manage a full range of respiratory disorders more easily than ever. Edited and written by leaders in the field, the book covers the scientific principles of respiratory medicine; its foundations in basic anatomy, physiology, pharmacology, pathology, and immunology; and its clinical applications. It features a wealth of new chapters * coverage of new modalities in biotechnologic, genomic, and informational sciences * a new 2-color design that makes it easier and quicker to access key information * and complete references for further study.

      New to this Edition:

• Covers the hottest topics in the field, including COPD guidelines and lung reduction surgery * better pharmacological control of asthma * first-line drug therapies for cancer * interstitial lung disease * thoracoscopic surgery * ARDS ventilation guidelines c and more.
• Includes 6 new chapters: Alveolar and Distal Airway Epithelial Fluid Transport * Mucus Production, Secretion, and Clearance * Pleuroscopy, Thoracoscopy, and Other Invasive Procedures * Clinical Exercise Testing * Smoking Hazards and Cessation * and Patient Education and Compliance.
• Offers a fresh editorial approach with the addition of 1 new editor.
• Features the work of 73 new authors, including international contributors.
• Incorporates 100 new full-color illustrations for a total of more than 1,250 images.

Table of Contents:

PART 1:  Scientific Principles of Respiratory Medicine

Section A.  Anatomy and Development of the Respiratory Tract

Chapter 1.    Anatomy of the Lungs

Chapter 2.     Lung Growth and Development

Chapter 3.     Genetic Approach to Lung Disease

Section B.  Respiratory Physiology

Chapter 4.    Ventilation, Blood Flow, and Gas Exchange

Chapter 5.     Respiratory System Mechanics and Energetics

Chapter 6.     Pulmonary Circulation and Regulation of Fluid Balance

Chapter 7.     Acid-Base Balance

Section C.  Respiratory Pharmacology

Chapter 8.     General Pharmacologic Principles

Chapter 9.     Airway Pharmacology

Chapter 10.   Pulmonary Vascular Pharmacology

Section D.  Defense Mechanisms and Immunology

Chapter 11.   Pulmonary Surfactant

Chapter 12.   Alveolar and Distal Airway Epithelial Fluid Transport

Chapter 13.   Mucus Production, Secretion, and Clearance

Chapter 14.   Monocytes, Macrophages, and Dendritic Cells of the Lung

Chapter 15.   Immune Recognition and Responses

Section E.  Respiratory Pathology and Inflammation

Chapter 16.   General Features of Respiratory Pathology

Chapter 17.   Inflammation, Injury, and Repair

PART 2:  Diagnosis and Evaluation of Respiratory Disease

Section F.  Diagnosis

Chapter 18.  History and Physical Examination

Chapter 19.  Microbiologic Diagnosis of Lower Respiratory Tract Infection

Chapter 20.  Radiographic Techniques

Chapter 21.  Nuclear Medicine Techniques

Chapter 22.  Bronchoscopy

Chapter 23.  Pleuroscopy, Thorascopy and Other Invasive Procedures

Section G.  Evaluation

Chapter 24.  Pulmonary Function Testing

Chapter 25.  Clinical Exercise Testing

Chapter 26.  Preoperative Evaluation

Chapter 27.  Evaluation of Respiratory Impairment/ Disability

PART 3:  Clinical Respiratory Medicine

Section H.  Symptoms of Respiratory Disease and Their Management

Chapter 28.  Dyspnea

Chapter 29.  Cough

Chapter 30.  Chest Pain

Section I.  Infectious Diseases of the Lungs

Chapter 31.  Viral Infections

Chapter 32.  Pyogenic Bacterial Pneumonia, Lung Abscess, and Empyema

Chapter 33.  Tuberculosis and Other Mycobacterial Diseases

Chapter 34.  Fungal Infections

Chapter 35.  Parasitic Infections

Section J.  Obstructive Diseases

Chapter 36.  Chronic Bronchitis and Emphysema

Chapter 37.  Asthma

Chapter 38.  Cystic Fibrosis

Chapter 39.  Bronchiectasis

Chapter 40.  Disorders of the Upper Airways

Chapter 41.  Disorders of the Intrathoracic Airways

Section K.  Neoplasms of the Lung

Chapter 42.  Biology of Lung Cancer

Chapter 43.  Epidemiology of Lung Cancer

Chapter 44.  Bronchogenic Carcinoma

Chapter 45.  Lymphoma, Lymphoproliferative Diseases, and Other Primary Malignant Tumors

Chapter 46.  Metastatic Malignant Tumors

Chapter 47.  Benign Tumors

Section L.  Disorders of the Pulmonary Circulation

Chapter 48.  Pulmonary Thromboembolism

Chapter 49.  Pulmonary Vasculitis and Primary Pulmonary Hypertension

Chapter 50.  Pulmonary Arteriovenous Malformations and Other Pulmonary Vascular Abnormalities

Chapter 51.  Pulmonary Edema and Acute Lung Injury

Chapter 52.  Cor Pulmonale

Section M.  Infiltrative and Interstitial Lung Diseases

Chapter 53.  Approach to Diagnosis and Management of the Idiopathic Interstitial Pneumonias

Chapter 54.  The Lungs and Connective Tissue Diseases

Chapter 55.  Sarcoidosis

Chapter 56.  Diffuse Alveolar Hemorrhage and Other Rare Infiltrative Disorders

Chapter 57.  Eosinophilic Lung Diseases

Chapter 58.  Lymphangioleiomyomatosis

Chapter 59.  Pulmonary Alveolar Proteinosis

Section N.  Environmental and Occupational Disorders

Chapter 60.  Occupational Asthma

Chapter 61.  Pneumoconioses

Chapter 62.  Hypersensitivity Pneumonitis

Chapter 63.  Air Pollution

Chapter 64.  Acute Pulmonary Responses to Toxic Exposures

Chapter 65.  High Altitude

Chapter 66.  Diving Medicine

Chapter 67.  Drug-Induced Pulmonary Disease

Section O.  Disorders of the Pleura

Chapter 68.  Pleural Effusion

Chapter 69.  Pneumothorax, Chylothorax, Hemothorax, and Fibrothorax

Chapter 70.  Tumors of the Pleura

Section P.  Disorders of the Mediastinum

Chapter 71.  Tumors and Cysts of the Mediastinum

Chapter 72.  Pneumomediastinum and Mediastinitis

Section Q.  Disorders in the Control of Breathing

Chapter 73.  Hypoventilation and Hyperventilation Syndromes

Chapter 74.  Sleep Disorders

Section R.  Respiratory Manifestations of Extrapulmonary Disorders

Chapter 75.  Pulmonary Complications of Human Immunodeficiency Virus Infection

Chapter 76.  Pulmonary Complications of Organ Transplantation and Primary Immunodeficiencies

Chapter 77.  Pulmonary Complications of Heart Disease

Chapter 78.  Pulmonary Complications of Abdominal Disease

Chapter 79.  Pulmonary Complications of Hematologic Disease

Chapter 80.  Pulmonary Complications of Endocrine Disease

Chapter 81.  The Lungs in Obstetric and Gynecologic Disease

Chapter 82.  The Lungs and Neuromuscular Diseases

Chapter 83.  The Lungs and Chest Wall Disease

Section S.  Management of Respiratory Failure

Chapter 84.  Principles of Mechanical Ventilation

Chapter 85.  Hypoxemic Respiratory Failure, Including Acute Respiratory Distress Syndrome

Chapter 86.  Acute Ventilatory Failure

Chapter 87.  Care at the End of Life for Patients with Respiratory Failure

Chapter 88.  Pulmonary Rehabilitation

Chapter 89.  Lung Transplantation

Section T.  Prevention and Control

Chapter 90.  Smoking Hazards and Cessation

Chapter 91.  Patient Education and Compliance

APPENDIX:  Glossary of Terms and Standard Symbols

INDEX