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Medical Science Books Medical Book Review: Molecular Mechanisms of Neurotransmitter Release edited by Zhao-Wen Wang provides the reader with a comprehensive overview of the complex interactions occurring in pre-synaptic neurons involved with chemical communication. Each chapter comprises a stand-alone monograph written by experts in the field focusing on different aspects of neurotransmitter release. Although synaptic junction research is an exceptionally prolific area of research and new studies are published weekly, the topics included in this volume represent a solid core of knowledge upon which further investigations of neurotransmission continue to build. In spite of the contributions from over 25 authors, a relatively consistent writing style was maintained throughout. Refreshingly, for a research science title, that style includes clear explanation and the elimination of jargon and abbreviations which don’t increase understanding. This makes the material highly approachable even by a student with a limited background in neuroscience but an interest in the subject material. Clarity of style is also not wasted on the active neuroscientist who may only have expertise in one area discussed in the text but requires a more rounded view of all the pertinent processes that are involved in axonal release of neurotransmitters. High quality illustrations, a large number of which are in full color, support the information in the text and are also available on a companion CD-ROM that is packaged with the book. This book is recommended for the researcher and student of neuroscience alike. Clinical professionals often don’t have time to delve into physiology texts due to strict time constraints, but Neurology residents undergoing specialty training in neuromuscular disease will find this book to be an invaluable resource. From the Publisher:
Within the complex neuronal network of the
nervous system, neuron-to-neuron
communication occurs mainly through chemical
synapses, where the presynaptic nerve
terminal releases neurotransmitters that
control the function of postsynaptic neurons
by acting on postsynaptic receptors. Recent
decades have brought groundbreaking new
developments and a wealth of knowledge to
this field. In Molecular Mechanisms of
Neurotransmitter Release, leading
experts provide concise, up-to-date
information on all major molecular
mechanisms involved, with complete
background information and figures and
diagrams to further elucidate key concepts
or experiments.
Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release is sure to provide a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for all those who have a general interest in the ever-evolving field of neuroscience. Content Level » Professional/practitioner Keywords » Chemical synapses - Endocytosis - Exocytosis - Neurotransmission - Presynaptic receptors Table of Contents: 1 The Architecture of the Presynaptic Release Site . . . . . . . . . . . . . . . . 1R. Grace Zhai 2 Multiple Modes of Fusion and Retrieval at the Calyx of Held Synapse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17Liming He, Benjamin D. McNeil, and Ling-Gang Wu 3 Roles of SNARE Proteins in Synaptic Vesicle Fusion . . . . . . . . . . . . . 35Mark T. Palfreyman and Erik M. Jorgensen 4 Roles and Sources of Calcium in Synaptic Exocytosis . . . . . . . . . . . . 61Zhao-Wen Wang, Bojun Chen, and Qian Ge 5 Regulation of Presynaptic Calcium Channels . . . . . . . . . . . . . . . . . . . 85Allen W. Chan and Elise F. Stanley 6 Synaptotagmin: Transducing Ca 2+-Bindingto Vesicle Fusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107Carin Loewen and Noreen Reist 7 Functional Interactions Among the SNARE Regulators UNC-13, Tomosyn, and UNC-18 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135Robby M. Weimer and Janet E. Richmond 8 Roles of the ELKS/CAST Family and SAD Kinase in Neurotransmitter Release . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157Toshihisa Ohtsuka and Yoshimi Takai 9 The Role of Potassium Channels in the Regulation of Neurotransmitter Release . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171Laurence O. Trussell and Michael T. Roberts 10 Modulation of Neurotransmitter Release and Presynaptic Plasticity by Protein Phosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . 187Zu-Hang Sheng 11 Synaptic Vesicle Endocytosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207Liesbet Smitz and Patrik Verstreken 12 Lipids and Secretory Vesicle Exocytosis . . . . . . . . . . . . . . . . . . . . . . . . 239Shona L. Osborne and Frederic A. Meunier 13 Neurotransmitter Reuptake and Synaptic Vesicle Refilling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263Richard J. Reimer, Kimberly A. Zaia, and Hiroaki Tani 14 Regulation of Neurotransmitter Release by Presynaptic Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297Matthew Frerking and Joyce Wondolowski 15 Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules . . . . . . . . . . . . . . . . 315Kensuke Futai and Yasunori Hayashi 16 Differential Regulation of Small Clear Vesicles and Large Dense-Core Vesicles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327Tao Xu and Pingyong Xu Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 341 |
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