From the Publisher:         

     Iron Transport in Bacteria, a survey of research conducted over the past 50 years, examines the advances in technology and the recent availability of sequences of microbial genomes that have led to an explosion of knowledge in the field of iron transport systems.  Analysis of genomes has identified new systems, and new models for transport have been suggested by crystallography and structural determinations of the membrane transport proteins.  Providing an overview of up-to-date information available on iron and microbial virulence, Iron Transport in Bacteria offers insight into development and future directions that will fascinate graduate and advanced undergraduate students and equip instructors in pathogenesis and infectious diseases.

     The book comprises five concise sections; the first discusses the structures, chemical properties, and biosynthesis of the microbial products, such as siderophores and hemophores used by these organisms to acquire iron.  The second section explores the transport of these compounds into gram-negative bacteria.  The remaining sections cover iron transport in the prototype, E. coli K-12; iron transport systems in selected pathogenic microorganisms; and iron transport in ecology.

Key Features

• Provides an up-to-date survey of iron transport systems in bacteria
• Details iron transport and its regulation in E. coli as a prototype for iron transport systems in gram-negative bacteria
• Includes chapters on the major gram-negative, gram-positive and acid-fast bacterial pathogens -- their iron transport systems and the roles of these systems in virulence
• Presents structural studies of siderophores, heme carriers, and iron transport proteins
• Discusses the ecology of siderophores and their potential therapeutic uses

Table of Contents:

I.  Siderophores and Hemophores:  Properties and Biosynthesis of Bacterial Iron and Heme Carriers

Chapter 1.     Biochemical and Physical Properties of Siderophores

Chapter 2.     Siderophore Biosynthesis in Bacteria

Chapter 3.     Hemophore-Dependent Heme Acquisition Systems

II.  Iron Transport Proteins:  Structural Studies

Chapter 4.     Structure of Outer Membrane Receptor Proteins

Chapter 5.     Bacterial Heme and Hemoprotein Receptors

Chapter 6.     Bacterial Heme Oxygenases

Chapter 7.     The TonB, ExbB, and ExbD Proteins

Chapter 8.     Periplasmic Binding Proteins Involved in Bacterial Iron Uptake

III.  Iron Transport, Energetics, and Regulation in Escherichia coli K-12:  A Prototype for Iron Transport Systems in Gram-Negative Bacteria

Chapter 9.     Iron Uptake via the Enterobacteria System

Chapter 10.   Transport Biochemistry of FepA

Chapter 11.   Ferrichrome-and Citrate-Mediated Iron Transport

Chapter 12.   Ferrous Iron Transport

Chapter 13.   Mode of Binding of the Fur Protein to Target DNA:  Negative Regulation of Iron-Controlled Gene Expression

IV.  Iron Transport Systems in Pathogenic Bacteria

Chapter 14.   Pathogenic Escherichia coli, Shigella, and Salmonella

Chapter 15.   Yersinia

Chapter 16.   Vibrio

Chapter 17.   Neisseria

Chapter 18.   Hemophilus

Chapter 19.   Pseudomonas

Chapter 20.   Bordetella

Chapter 21.   Porphyromonas gingivalis

Chapter 22.   Corynebacterium diptheriae

Chapter 23.   Pathogenic Mycobacteria

Chapter 24.   Legionella

Chapter 25.   Staphylococcus, Streptococcus, and Bacillus

Chapter 26.   Erwinia, a Plant Pathogen

Chapter 27.   Therapeutic Uses of Iron (III) Chelators and Their Antimicrobial Conjugates

V.  Iron Transport and Ecology

Chapter 28.   Ecology of Siderophores

Chapter 29.   Environmental Fluorescent Pseudomonas and Pyverdine Diversity:  How Siderophores Could Help Microbiologists in Bacterial Identification and Taxonomy

Chapter 30.   Mechanisms and Regulation of Iron Uptake in the Rhizobia

INDEX