Table of Contents

VOLUME ONE:

Epidemiology

Chapter 1.     Classification of Diabetes Mellitus and Other Categories of Glucose Intolerance

Chapter 2.     Epidemiology and Geography of Type I Diabetes Mellitus

Chapter 3.     Epidemiology and Geography of Type 2 Diabetes Mellitus

Normal Physiology of Pancreatic Function

Chapter 4.     Development and Life Cycle of a β-Cell

Chapter 5.     Morphology of the Pancreas in Normal and Diabetic States

Chapter 6.     Insulin Gene Expression and Biosynthesis

Chapter 7.     β-Cell Biology of Insulin Secretion

Chapter 8.     Normal Insulin Secretion in Humans

Chapter 9.     Neuropeptides and Insulin Secretion

Chapter 10.   Biological Effects of C-Peptide and Proinsulin

Chapter 11.   Biosynthesis, Secretion, and Action of Glucagon

Chapter 12.   Islet Amyloid Polypeptide/GLP-1/Exendin

Normal Physiology of Insulin Action

Chapter 13.   Mechanisms of Insulin Signal Transduction

Chapter 14.   Regulation of Glucose Metabolism in the Liver

Chapter 15.   Insulin Action In Vivo:  Glucose Metabolism

Chapter 16.   Measuring Insulin Action In Vivo

Chapter 17.   Protein Metabolism in Health and Diabetes

Chapter 18.   Lipid and Lipoprotein Metabolism

Chapter 19.   Insulin Regulation of Ketone Body Metabolism

Pathogenesis

Chapter 20.   The Insulin Resistance Syndrome

Chapter 21.   β-Cell Dysfunction in Type 2 Diabetes

Chapter 22.   Metabolic and Molecular Pathogenesis of Type 2 Diabetes Mellitus

Chapter 23.   Genome Scans of Type 2 Diabetes Mellitus

Chapter 24.   Molecular Genetics of Type 2 Diabetes- Candidate Genes

Chapter 25.   Glucose Toxicity

Chapter 26.   Monogenic Disorders of the β-Cell

Chapter 27.   Immunopathogenesis of Type 1 Diabetes

Chapter 28.   Molecular Genetics of Type 1 Diabetes

Chapter 29.   Diabetes Secondary to Acquired Disease of the Pancreas

Obesity

Chapter 30.   The Relationship Between Obesity and Type 2 Diabetes- The Role of Neuroendocrine and Autonomic Factors

Chapter 31.   Is Type 2 Diabetes the Result of a "Thrifty Genotype" or a "Thrifty Phenotype"?

Chapter 32.   The Genetics of Human Obesity

Chapter 33.   The Role of Energy Expenditure in the Regulation of Energy Balance

Chapter 34.   Role of the Adipocyte in Type 2 Diabetes

Chapter 35.   Lipodystrophies and Diabetes

Chapter 36.   Treatment of Obesity

Chapter 37.   Animal Models of Obesity

Chapter 38.   The Role of the Hypothalamus in the Maintenance of Energy Balance and Peripheral Glucose Control

Management of Diabetes:  Diet, Exercise, and Drugs

Chapter 39.   Dietary Management of Diabetes Mellitus in Europe and North America

Chapter 40.   Dietary Management of Diabetes Mellitus in India and South East Asia

Chapter 41.   Dietary Management of Diabetes Mellitus:  Japanese Guidance and Methodology

Chapter 42.   Dietary Management of Diabetes Mellitus in Sub-Saharan Africa

Chapter 43.   Exercise

Chapter 44.   Should We Treat Impaired Glucose Tolerance and Impaired Fasting Glucemia?

Chapter 45.   Sulfonylureas:  Basic Aspects and Clinical Uses

Chapter 46.   Megalitinides:  Basic Aspects and Clinical Uses

Chapter 47.   Metformin and Other Biguanides:  Pharmacology and Therapeutic Usage

Chapter 48.   Thiazolidinediones as PPAR Agonists

Chapter 49.   α-Glucosidase Inhibitors

Chapter 50.   Combination Therapy in Type 2 Diabetes

Chapter 51.   New Drugs for the Treatment of Diabetes Mellitus

Chapter 52.   Hypolipidemic Agents and Their Role in the Therapy of Diabetes Mellitus

Chapter 53.   Effective Insulin Therapy

VOLUME TWO:

Management of Diabetes :  Monitoring the Other Interventions

Chapter 54.   Alternative Routes of Insulin Delivery

Chapter 55.   Implantable Pumps

Chapter 56.   Artificial and Bio-artificial Pancreas System

Chapter 57.   Pancreas Transplantation

Chapter 58.   Islet Transplantation

Chapter 59.   Hypoglycemia

Chapter 60.   Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State

Chapter 61.   Complications of Insulin Therapy

Complications:  General and Microvascular

Chapter 62.   Pathogenesis of Diabetic Microvascular Complications

Chapter 63.   The Role of Glycemia in Diabetic Complications

Chapter 64.   The Microcirculation in Diabetes Mellitus

Chapter 65.   Diabetic Retinopathy

Chapter 66.   Nonretinal Ocular Complications of Diabetes Mellitus

Chapter 67.   Preserving Vision

Chapter 68.   Diabetic Nephropathy

Chapter 69.   The Pathology of Diabetic Neuropathy

Chapter 70.   Autonomic Neuropathy

Chapter 71.   Connective Tissue Disorders in Diabetes

Chapter 72.   Peridontal Disease and Diabetes Mellitus

Chapter 73.   The Diabetic Foot

Chapter 74.   Erectile Dysfunction in Diabetes Mellitus

Complications:  Macrovascular Disease

Chapter 75.   Epidemiology of Macrovascular Disease and Hypertension in Diabetes Mellitus

Chapter 76.   Effect of Intensive Glycemic Control on Macrovascular Events in Patients with Diabetes Mellitus

Chapter 77.   The Syndrome of Insulin Resistance and its Links to Atherosclerosis

Chapter 78.   Metabolic Stress and Atherosclerosis

Chapter 79.   Endothelial Function and Dysfunction

Chapter 80.   Hemostatic Abnormalities in Diabetes

Chapter 81.   Atherogenesis and Coronary Heart Disease

Chapter 82.   Clinical Features and Treatment of Coronary Heart Disease in Diabetes

Chapter 83.   Arterial Hypertension in Diabetes:  Etiology and Treatment

Chapter 84.   Cerebrovascular Disease in Diabetes Mellitus

Chapter 85.   Peripheral Vascular Disease in Diabetes

Management of Diabetes:  Glucose and Lipid Monitoring, Specific Subgroups

Chapter 86.   Diabetes Mellitus in Children and Adolescence

Chapter 87.   Difficult Diabetes

Chapter 88.   Diabetes Mellitus, Pregnancy, and Gestational Diabetes

Chapter 89.   Aging and Diabetes Mellitus

Chapter 90.   Education of the Diabetic Patient

Chapter 91.   Psychological Problems and Management of Patients with Diabetes Mellitus

Chapter 92.   Computer-Assisted Diabetes Education and Information Technology in Diabetes Care

Chapter 93.   Monitoring Diabetes with Urine Tests

Chapter 94.   Self-Monitoring of Blood Glucose

Chapter 95.   Glucose Sensors:  Present and Future

Chapter 96.   Glycated Hemoglobin and Serum Proteins as Tools for Monitoring

Chapter 97.   Monitoring of Lipids in Diabetes

Chapter 98.   Infection, Immunity, and Diabetes

Chapter 99.   The Care of the Diabetic Patient During Surgery

Diabetes and Public Health

Chapter 100.  Screening for Diabetes and Glucose Intolerance

Chapter 101.  Organization of Care:  The "At Risk" Person in the Community

Chapter 102.  Diabetes and Public Health in the United States

Chapter 103.  Organization of Care:  Western Pacific Region (China and Hong Kong as Examples)

Chapter 104.  Organization of Care:  Problems in Developing Countries--The Asian Continent

Chapter 105.  Organization of Care:  Problems in Developing Countries--Sub-Saharan Africa

Chapter 106.  Organization of Care:  Problems in Developing Countries--South America

Chapter 107.  Organization of Care:  Diabetes Community Programs

Chapter 108.  Life with Diabetes Problems:  Human and Social Rights

Chapter 109.  Economics of Care:  Europe

Chapter 110.  Economics of Care:  The Americas

Chapter 111.   Economics of Care:  South and East Asia

Chapter 112.  Economics of Care:  Australia and New Zealand

Chapter 113.  Economics of Care:  The Middle East

Chapter 114.  Diabetes Cost:  Sub-Saharan Africa Perspective

Chapter 115.  Prevention of Type 1 Diabetes Mellitus

Chapter 116.  Prevention of Type 2 Diabetes Mellitus