From the Publisher:

     The revised and updated 2nd Edition provides a logical, practical framework for managing patients with hypertension.  Today's leading experts discuss all aspects of the field- from pathophysiology, pharmacological treatments, and lifestyle modifications to secondary hypertension and cardiovascular complications.

     Inside you'll find...

• An assessment of the risks of specific pharmacological treatments to help you decide when and how to aggressively treat each patient.

• Expert analysis of the results of recent clinical trials and ways to translate those data into everyday clinical practice.

• Comprehensive coverage updated throughout--including 14 new chapters that detail the very latest developments.

• Guidelines for selecting the appropriate drugs.

• Strategies for managing patients with comorbid conditions, such as diabetes, renal disease, and ischemic heart disease.

• An explanation of the role of vascular biology in the pathogenesis of hypertension.

• Clinical pearls throughout highlighting experts' practice-proven approaches-preferred treatment boxes summarizing key treatment recommendations and evidence-based therapeutic ladders that summarize various therapy regimens.

• More than 300 illustrations-including algorithms and tables-for at-a-glance guidance.

     Comprehensive and authoritative, this all-in-one resource presents the most up-to-date information on diagnosis and treatment!

Table of Contents:

Section 1.  Background and History

Chapter 1.     A History of Hypertension Treatment

Chapter 2.     The National High Blood Pressure Education Program

Chapter 3.     Epidemiology of Hypertension   

Section 2.  Pathophysiology

Chapter 4.     Pathophysiology of Hypertension

Chapter 5.     Blood Pressure Genetics

Chapter 6.     The Sympathetic Nervous System in Acute and Chronic Blood Pressure Elevation

Chapter 7.     Environmental and Psychosocial Stress in Hypertension Onset and Progression

Chapter 8.     Renin

Chapter 9.     Angiotensin-Converting Enzymes:  Properties and Functions

Chapter 10.   Angiotensin-(1-7)

Chapter 11.   The Angiotensin Receptors AT₁ and AT₂

Chapter 12.   Aldosterone and Mineralocorticoids

Chapter 13.   The Role of Insulin Resistance and Compensatory Hyperinsulinemia in Patients with Essential Hypertension

Chapter 14.   Remodeling of Resistance Arteries in Hypertension

Chapter 15.   Clinical Applications of Arterial Stiffness in Hypertension

Chapter 16.   Endothelium in Hypertension:  Nitric Oxide

Chapter 17.   Endothelin in Hypertension

Chapter 18.   Natriuretic Peptides

Chapter 19.   Vasodilator Peptides:  CGRP, Substance P, and Adrenomedullin

Chapter 20.   The Kallikrein-Kinin System as a Regulator of Cardiovascular and Renal Function

Section 3.  Target Organ Damage/ Cardiovascular Events

Chapter 21.   The Concept of Total Risk

Chapter 22.   New Interpretations of Blood Pressure:  The Importance of Pulse Pressure

Chapter 23.   Coronary Atherosclerotic Sequalae of Hypertension

Chapter 24.   Left Ventricular Hypertrophy, Congestive Heart Failure, and Coronary Flow Reserve Abnormalities in Hypertension

Chapter 25.   Renal Protection in Chronic Kidney Disease

Section 4.  Diagnosis

Chapter 26.   Initial Evaluation and Follow-Up Assessment

Chapter 27.   Prognostic and Diagnostic Value of Ambulatory Blood Pressure Monitoring

Chapter 28.   White-Coat Hypertension

Section 5.  Treatment:  General Considerations

Chapter 29.   The Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC)

Chapter 30.   The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

Chapter 31.   The LIFE Study

Chapter 32.   The VALUE Trial

Chapter 33.   Main Results from VALUE

Chapter 34.   Clinical Outcome Trials of Hypertension with Angiotensin Receptor Blockers

Chapter 35.   ACE Inhibitor Trials:  Effects in Hypertension

Chapter 36.   Critical Assessment of Hypertension Guidelines

Chapter 37.   Current Prescribing Practices

Chapter 38.   Calcium Channel Blockers:  Controversies, Lessons, and Outcomes

Chapter 39.   Nursing Clinics in the Management of Hypertension

Chapter 40.   Community Outreach

Chapter 41.   Medication Adherence for Antihypertensive Therapy

Section 6.  Diet and Nutrition

Chapter 42.   Diet:  Micronutrients

Chapter 43.   Dietary Approaches to Hypertension Management:  The DASH Studies

Chapter 44.   Obesity and Hypertension:  Impact on the Cardiovascular and Renal Systems

Chapter 45.   Alcohol and Hypertension

Chapter 46.   Obesity in Hypertension:  The Role of Diet and Drugs

Chapter 47.   Exercise and Hypertension

Section 7.  Pharmacologic Treatment

Chapter 48.   Initial Choices in the Treatment of Hypertension

Chapter 49.   Pharmacokinetics of Antihypertensive Drugs

Chapter 50.   Fixed Combination Antihypertensive Therapy

Chapter 51.   Chronotherapeutics in the Treatment of Hypertension

Section 8.  Comorbid Conditions and Special Populations in Hypertension

Chapter 52.   Diabetes Mellitus and the Cardiovascular Metabolic Syndrome:  Reducing Cardiovascular and Renal Events

Chapter 53.   Hypertension in Patients on Renal Replacement Therapy

Chapter 54.   Ischemic Heart Disease in Hypertension

Chapter 55.   Hypertension in the Elderly

Chapter 56.   Management of Hypertension in Black Populations

Chapter 57.   Hypertension in Pregnancy

Chapter 58.   Hypertension in Children

Chapter 59.   Resistant Hypertension

Chapter 60.   Orthostatic Hypotension and Autonomic Dysfunction Syndromes

Section 9.  Individual Drug Classes

Chapter 61.   How Antihypertensive Drugs Get Approved in the United States

Chapter 62.   Diuretics:  Mechanisms of Action

Chapter 63.   β-Adrenergic Blockers

Chapter 64.   α-Adrenoceptor Blockers

Chapter 65.   Angiotensin-Converting Enzyme Inhibitors

Chapter 66.   Calcium Antagonists

Chapter 67.   Angiotensin II Receptor Antagonists

Chapter 68.   Direct-Acting Smooth Muscle Vasodilators and Adrenergic Inhibitors

Chapter 69.   Endothelin Antagonists

Chapter 70.   Mineralocorticoid Receptor Antagonists

Chapter 71.   Vasopeptidase Inhibitors

Chapter 72.   Renin Inhibitors

Section 10.  Secondary Hypertension

Chapter 73.   Obstructive Sleep Apnea and Hypertension

Chapter 74.   Renovascular Hypertension:  Diagnosis and Treatment

Chapter 75.   Adrenal Cortex Hypertension

Chapter 76.   Pheochromocytoma:  Detection and Management

Chapter 77.   Anesthesia and Hypertension

Chapter 78.   Management of Hypertensive Emergencies and Urgencies

Chapter 79.   Aggressive Blood Pressure Targets:  Developing Effective Algorithms

Appendix:  Drug Tables

Index