Contributors
 

Preface

 

Part 1
 

Introduction to Clinical Medicine

 

1
The Practice of Medicine

The Editors

 

2
Global Issues in Medicine

Jim Yong Kim / Paul Farmer

 

3
Decision-Making in Clinical Medicine

Daniel B. Mark

 

4
Screening and Prevention of Diseases

Gary J. Martin

 

5
Principles of Clinical Pharmacology

Dan M. Roden

 

6
Women’s Health

Andrea Dunaif

 

7
Medical Disorders during Pregnancy

Robert L. Barbieri / John T. Repke

 

8
Medical Evaluation of the Surgical Patient

Wei C. Lau / Kim A. Eagle


 

9
Geriatric Medicine

Lisa B. Caruso / Rebecca A. Silliman

 

10
Complementary and Alternative Medicine

Stephen E. Straus

 

11
Palliative and End-of-Life Care

Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel

 

e1
The Safety and Quality of Health Care

David W. Bates

 

e2
Economic Considerations in the Practice of Medicine

David Meltzer

 

e3
Racial and Ethnic Disparities in Health Care
Joseph R. Betancourt / David Blumenthal

 

e4
Ethical Issues in Clinical Medicine

Bernard Lo


 

Part 2
 

Cardinal Manifestations and Presentation of Diseases

 

Section 1
 

Pain

 

12
Pain: Pathophysiology and Management

Howard L. Fields / Joseph B. Martin

 

13
Chest Discomfort

Thomas H. Lee

 

14
Abdominal Pain

William Silen

 

15
Headache

Peter J. Goadsby / Neil H. Raskin

 

16
Back and Neck Pain

John W. Engstrom

 

Section 2
 

Alterations in Body Temperature

 

17
Fever and Hyperthermia

Charles A. Dinarello / Reuven Porat

 

18
Fever and Rash

Elaine T. Kaye / Kenneth M. Kaye

 

e5
Atlas of Rashes Associated with Fever

Elaine T. Kaye / Kenneth M. Kaye

 

19
Fever of Unknown Origin

Jeffery A. Gelfand / Michael V. Callahan

 

20
Hypothermia and Frostbite

Daniel F. Danzl

 

Section 3
 

Nervous System Dysfunction

 

21
Syncope

Mark D. Carlson

 

22
Dizziness and Vertigo

Robert B. Daroff

 

23
Weakness and Paralysis

Michael J. Aminoff

 

24
Gait and Balance Disorders

Lewis Sudarsky

 

25
Numbness, Tingling, and Sensory Loss

Michael J. Aminoff / Arthur K.Asbury

 

26
Confusion and Delirium

S. Andrew Josephson / Bruce L. Miller

 

e6
Memory Loss

Thomas D. Bird / Bruce L. Miller


 

27
Aphasia, Memory Loss, and Other Focal Cerebral Disorders

M.-Marsel Mesulam

 

28
Sleep Disorders

Charles A. Czeisler / John W. Winkleman / Gary S. Richardson


 

Section 4
 

Disorders of Eyes, Ears, Nose, and Throat

 

29
Disorders of the Eye

Jonathan C. Horton

 

30
Disorders of Smell, Taste, and Hearing

Anil K. Lalwani

 

31
Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Infections

Michael A. Rubin / Ralph Gonzales / Merle A. Sande

 

32
Oral Manifestations of Disease

Samuel C. Durso

 

e7
Atlas of Oral Manifestations of Disease

Samuel C. Durso / Janet A. Yellowitz

 

Section 5
 

Alterations in Circulatory and Respiratory Functions


 

33
Dyspnea and Pulmonary Edema


Richard M. Schwartzstein

 

34
Cough and Hemoptysis

Steven E. Weinberger / David A. Lipson

 

35
Hypoxia and Cyanosis

Eugene Braunwald

 

36
Edema

Eugene Braunwald / Joseph Loscalzo

 

e8
Approach to the Patient with a Heart Murmur

Patrick O’Gara / Eugene Braunwald

 

37
Palpitations

Joseph Loscalzo


 

Section 6
 

Alterations in Gastrointestinal Function

 

38
Dysphagia

Raj K. Goyal

 

39
Nausea, Vomiting, and Indigestion

William L. Hasler

 

40
Diarrhea and Constipation

Michael Camilleri / Joseph A. Murray

 

41
Weight Loss

Carol M. Reife

 

42
Gastrointestinal Bleeding

Loren Laine

 

43
Jaundice

Daniel S. Pratt / Marshall M. Kaplan

 

44
Abdominal Swelling and Ascites

Robert M. Glickman / Roshini Rajapaksa

 

Section 7
 

Alterations in Renal and Urinary Tract Function

 

45
Azotemia and Urinary Abnormalities
Bradley M. Denker / Barry M. Brenner

 

e9
Atlas of Urinary Sediments and Renal Biopsies

Agnes B. Fogo / Eric G. Neilsen

 

46
Fluid and Electrolyte Disturbances

Gary G. Singer / Barry M. Brenner

 

47
Hypercalcemia and Hypocalcemia
Sundeep Khosla

 

48
Acidosis and Alkalosis

Thomas B. DuBose, Jr.

 

Section 8
 

Alterations in Sexual Function and Reproduction

 

49
Sexual Dysfunction

Kevin T. McVary

 

50
Hirsutism and Virilization

David A. Ehrmann

 

51
Menstrual Disorders and Pelvic Pain

Janet E. Hall

 

Section 9
Alterations in the Skin

 

52
Approach to the Patient with a Skin Disorder

Thomas J. Lawley / Kim B. Yancey

 

53
Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders

Calvin O. McCall / Thomas J. Lawley

 

54
Skin Manifestations of Internal Disease
Jean L. Bolognia / Irwin M. Braverman

 

55
Immunologically Mediated Skin Diseases

Kim B. Yancey / Thomas J. Lawley

 

56
Cutaneous Drug Reactions
Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub


 

57
Photosensitivity and Other Reactions to Light

David R. Bickers


 

e10
Atlas of Skin Manifestations of Internal Disease

Thomas J. Lawley / Stephen Templeton


 

Section 10
 

Hematologic Alterations


 

58
Anemia and Polycythemia

John W. Adamson / Dan L. Longo

 

59
Bleeding and Thrombosis

Barbara A. Konkle

 

60
Enlargement of Lymph Nodes and Spleen

Patrick H. Henry / Dan L. Longo

 

61
Disorders of Granulocytes and Monocytes

Steven M. Holland /John I. Gallin

 

e11
Atlas of Hematology and Analysis of Peripheral Blood Smears

Dan L. Longo

 

Part 3
Genetics and Disease

 

62
Principles of Human Genetics

J. Larry Jameson / Peter Kopp

 

63
Chromosome Disorders

Terry Hassold / Stuart Schwartz

 

64
The Practice of Genetics in Clinical Medicine

Susan Miesfeldt / J. Larry Jameson

 

65
Gene Therapy in Clinical Medicine
Katherine A. High

 

Part 4
 

Regenerative Medicine

 

66
Stem Cell Biology

Minoru S. H. Ko

 

67
Applications of Stem Cell Biology in Clinical Medicine

Jack A. Kessler

 

68
Hematopoietic Stem Cells

David T. Scadden / Dan L. Longo

 

69
Tissue Engineering

Jennifer Anderson /Joseph P. Vacanti

 

Part 5
 

Nutrition

 

70
Nutritional Requirements and Dietary Assessment

Johanna Dwyer

 

71
Vitamin and Trace Mineral Deficiency and Excess

Robert M. Russell / Paolo M. Suter


 

72
Malnutrition and Nutritional Assessment

Douglas C. Heimburger

 

73
Enteral and Parenteral Nutrition Therapy

Bruce R. Bistrian / David F. Driscoll

 

74
Biology of Obesity

Jeffrey S. Flier / Eleftheria Maratos-Flier

 

75
Evaluation and Management of Obesity

Robert F. Kushner

 

76
Eating Disorders

B. Timothy Walsh


 

Part 6
 

Oncology and Hematology

 

Section 1
 

Neoplastic Disorders

 

77
Approach to the Patient with Cancer

Dan L. Longo

 

78
Prevention and Early Detection of Cancer

Otis W. Brawley / Barnett S. Kramer

 

79
Cancer Genetics

Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein

 

80
Cancer Cell Biology and Angiogenesis

Robert G. Fenton / Dan L. Longo

 

81
Principles of Cancer Treatment

Edward A. Sausville / Dan L. Longo

 

82
Infections in Patients with Cancer

Robert Finberg

 

83
Cancer of the Skin


Arthur J. Sober / Hensin Tsao / Carl V. Washington

 

84
Head and Neck Cancer


Everett E. Vokes

 

85
Neoplasms of the Lung


John D. Minna / Joan H. Schiller

 

86
Breast Cancer

Marc E. Lippman

 

87
Gastrointestinal Tract Center

Robert J. Mayer

 

88
Tumors of the Liver and Biliary Tree

Brian I. Carr


 

89
Pancreatic Cancer

Yu Jo Chua / David Cunningham

 

90
Bladder and Renal Cell Carcinomas

Howard I. Scher / Robert J. Motzer


 

91
Benign and Malignant Diseases of the Prostate

Howard I. Scher

 

92
Testicular Cancer

Robert J. Motzer / George J. Bosl

 

93
Gynecologic Malignancies

Robert C. Young

 

94
Soft Tissue and Bone Sarcomas and Bone Metastases

Shreyaskumar R. Patel / Robert S. Benjamin

 

95
Carcinoma of Unknown Primary

Gauri R. Varadhachary /James L. Abbruzzese

 

96
Paraneoplastic Syndromes: Endocrinologic/Hematologic

J. Larry Jameson / Bruce E. Johnson

 

97
Paraneoplastic Neurologic Syndromes

Joseph Dalmau / Myrna R. Rosenfeld

 

e12
Thymoma

Dan L. Longo

 

e13
Late Consequences of Cancer and Its Treatment

Michael C. Perry / Dan L. Longo


 

Section 2
 

Hematopoietic Disorders

 

98
Iron Deficiency and Other Hypoproliferative Anemias

John W. Adamson

 

99
Disorders of Hemoglobin

Edward J. Benz

 

100
Megaloblastic Anemia

A. Victor Hoffbrand

 

101
Hemolytic Anemias and Anemias due to Acute Blood Loss

Lucio Luzzatto

 

102
Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes

Neal S. Young

 

103
Polycythemia Vera and Other Myeloproliferative Diseases

Jerry L. Spivak

 

104
Acute and Chronic Myeloid Leukemia

Meir Wetzler /John C. Byrd / Clara D. Bloomfield

 

105
Malignancies of Lymphoid Cells

Dan L. Longo

 

106
Plasma Cell Disorders

Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson

 

107
Transfusion Biology and Therapy

Jeffery S. Dzieczkowski / Kenneth C. Anderson


 

108
Hematopoietic Cell Transplantation

Frederick R. Applebaum

 

Section 3
 

Disorders of Hemostasis

 

109
Disorders of Platelets and Vessel Wall

Barbara A. Konkle

 

110
Coagulation Disorders

Valder Arruda / Katherine High

 

111
Thrombosis Venous

F.R. Rosendaal / H.R. Büller

 

112
Antiplatelet, Anticoagulant, and Fibrinolytic Drugs

Jeffery L. Weitz
 

Part 7
 

Infectious Diseases

 

Section 1
 

Basic Considerations in Infectious Diseases

 

113
Introduction to Infectious Diseases: Host-Pathogen Interactions

Lawrence C. Madoff / Dennis L. Kasper

 

114
Molecular Mechanisms of Microbial Pathogenesis

Gerald B. Pier

 

115
Approach to the Acutely Ill Infected Febrile Patient

Tamar F. Barlam / Dennis L. Kasper

 

116
Immunization Principles and Vaccine Use

Gerald T. Keusch / Kenneth J. Bart / Mark Miller

 

117
Health Advice for International Travel

J.S. Keystone / P.E. Kozarsky

 

e14
Laboratory Diagnosis of Infectious Diseases

Alexander J. McAdam / Andrew B. Onderdonk

 

Section 2
 

Clinical Syndromes: Community-Acquired Infections

 

118
Infective Endocarditis

Adolf W. Karchmer

 

119
Infections of the Skin, Muscle, and Soft Tissues

Dennis L. Stevens

 

120
Osteomyelitis

Jeffrey Parsonnet

 

121
Intraabdominal Infections and Abscesses

Miriam J. Baron / Dennis L. Kasper

 

122
Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning

Joan R. Butterton / Stephen B. Calderwood

 

123
Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis

Dale N. Gerding / Stuart Johnson

 

124
Sexually Transmitted Infections: Overview and Clinical Approach

King K. Holmes

 

e15
Infectious Complications of Bites and Burns

Lawrence C. Madoff / Florencia Pereyra

 

Section 3
 

Clinical Syndromes: Nosocomial Infections

 

125
Health Care-Associated Infections

Robert A. Weinstein

 

126
Infections in Transplant Recipients

Robert Finberg /Joyce Fingeroth


 

Section 4
 

Approach to Therapy for Bacterial Diseases

 

127
Treatment and Prophylaxis of Bacterial Infections

Gordon L. Archer / Ronald E. Polk

 

Section 5
 

Diseases Caused by Gram-Positive Bacteria

 

128
Pneumococcal Infections

Daniel M. Musher

 

129
Staphylococcal Infections

Franklin D. Lowy

 

130
Strepococcal and Enterococcal Infections

Michael R. Wessels

 

131
Diphtheria and Other Infections Caused by Corynebacteria and Related Species

William R. Bishai / Jack R. Murphy

 

132
Infections Caused by Listeria monocytogenes

Elizabeth L. Hohmann / Daniel A. Portnoy

 

133
Tetanus

Elias Abrutyn

 

134
Botulism

Elias Abrutyn

 

135
Gas Gangrene and Other Clostridial Infections

Dennis L. Kasper /Lawrence C. Madoff


 

Section 6
 

Diseases Caused by Gram-Negative Bacteria

 

136
Meningococcal Infections

Lee M. Wetzler

 

137
Gonococcal Infections

Sanjay Ram / Peter A. Rice

 

138
Moraxella Infections

Daniel M. Musher

 

139
Haemophilus Infections

Timothy F. Murphy

 

140
Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria

Tamar F. Barlam / Dennis L. Kasper

 

141
Legionella Infection

Miguel Sabria / Victor L. Yu

 

142
Pertussis and Other Bordetella Infections

Scott A. Halperin

 

143
Diseases Caused by Gram-Negative Enteric Bacilli

Thomas A. Russo / James R. Johnson

 

144
Helicobacter Pylori Infections

John C. Atherton / Martin J. Blaser

 

145
Infections Due to Pseudomonas Species and Related Organisms

Reuben Ramphal

 

146
Salmonellosis

David A. Pegues / Samuel I. Miller

 

147
Shingellosis

Philippe Sansonetti / Jean Bergounioux

 

148
Infections Due to Campylobacter and Related Species

Martin J. Blaser

 

149
Cholera and Other Vibrioses

Matthew K. Waldor / Gerald T. Keusch

 

150
Brucellosis

Michael J. Corbel / Nicholas J. Beeching

 

151
Tularemia

Richard F. Jacobs / Gordon E. Schutze

 

152
Plague and Other Yersnia Infections

David T. Dennis / Grant L. Campbell

 

153
Bartonella Infections, Including Cat-Scratch Disease

David H. Spach / Emily Darby

 

154
Donovanosis

Gavin Hart

 

Section 7
 

Miscellaneous Bacterial Infections

 

155
Nocardiosis

Gregory A. Filice

 

156
Actinomycosis

Thomas A. Russo

 

157
Infections Due to Mixed Anaerobic Organisms

Dennis L. Kasper / Ronit Cohen-Poradosu

 

Section 8
 

Mycobacterial Diseases

 

158
Tuberculosis

Mario C. Raviglione / Richard J. O’Brien

 

159
Leprosy (Hansen’s Disease)

Robert H. Gelber

 

160
Nontuberculous Mycobacteria

C. Fordham von Reyn

 

161
Antimycobacterial Agents

Richard J. Wallace / David E. Griffith

 

Section 9
Spirochetal Disease

 

162
Syphilis

Sheila A. Lukehart

 

163
Endemic Treponematoses

Sheila A. Lukehart

 

164
Leptospirosis

Peter Speelman / Rudy Harkskeerl

 

165
Relapsing Fever

David T. Dennis

 

166
Lyme Borreliosis

Allen C. Steere
 

Section 10
Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia

 

167
Rickettsial Diseases

David H. Walker / J. Stephen Dumler / Thomas Marrie

 

168
Infections Due to Mycoplasmas

William M. McCormack

 

169
Chlamydial Infections

Walter E. Stamm

 

Section 11
 

Viral Diseases: General Considerations

 

170
Medical Virology

Fred Wang /Elliott Kieff

 

171
Antiviral Chemotherapy, Excluding Antiretroviral Drugs

Lindsey R. Baden / Raphael Dolin

 

Section 12
 

Infections Due to DNA Viruses


 

172
Herpes Simplex Viruses

Lawrence Corey

 

73
Varicella-Zoster Virus Infections

Richard J. Whitley

 

174
Epstein-Barr Virus Infections, Including Infectious Mononucleosis

Jeffery I. Cohen

 

175
Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8

Martin S. Hirsch

 

176
Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox Virus

Fred Wang

 

177
Parvovirus Infections

Kevin E. Brown

 

178
Human Papillomavirus Infections

Richard C. Reichman

 

Section 13
 

Infections Due to DNA and RNA Respiratory Viruses


 

179
Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)

Raphael Dolin

 

180
Influenza

Raphael Dolin

 

Section 14
 

Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

 

181
The Human Retroviruses

Dan L. Longo /Anthony S. Fauci

 

182
Human Immunodeficiency Virus Disease: AIDS and Related Disorders

Anthony S. Fauci / H. Clifford Lane



 

Section 15
 

Infections Due to RNA Viruses

 

183
Viral Gastroenteritis

Umesh D. Parashar / Roger I. Glass

 

184
Enterovirus and Reoviruses Infections

Jeffery I. Cohen

 

185
Measles (Rubeola)

Anne Gershon


 

186
Rubella (German Measles)

Anne Gershon

 

187
Mumps

Anne Gershon

 

188
Rabies and Other Rhabdovirus Infections

Alan C. Jackson / Eric C. Johannsen

 

189
Infections Caused by Arthropod and Rodent-Borne Viruses

Clarence J. Peters

 

190
Ebola and Marburg Viruses

Clarence J. Peters


 

Section 16
 

Fungal and Algal Infections

 

191
Diagnosis and Treatment of Fungal Infections

John E. Edwards

 

192
Histoplasmosis

Chadi A. Hage / L. Joseph Wheat

 

193
Coccidioidomycosis

Neil M. Ampel

 

194
Blastomycosis

Stanley W. Chapman

 

195
Cryptococcosis

Arturo Casadevall

 

196
Candidiasois


John E. Edwards

 

197
Aspergillosis

David W. Denning

 

198
Mucormycosis

Alan M. Sugar

 

199
Miscellaneous Mycoses and Algal Infections

Stanley W. Chapman / Donna C. Sullivan

 

200
Pneumocystis Infection

A. Geroge Smulian /Peter D. Walzer


 

Section 17
 

Protozoal and Helminthic Infections: General Considerations

 

e16
Laboratory Diagnosis of Parasitic Infections

Sharon L. Reed / Charles E. Davis

 

201
Agents Used to Treat Parasitic Infections

Thomas A. Moore

 

e17
Pharmacology of Agents Used to Treat Parasitic Infections

Thomas A. Moore

 

Section 18
 

Protozoal Infections

 

202
Ambiasis and Infection with Free-Living Amebas

Sharon L. Reed

 

203
Malaria

Nicholas J. White / Joel G. Breman

 

204
Babesiosis

Jeffery Gelfand

 

e18
Atlas of Blood Smears of Malaria and Babesiosis

Nicholas J. White / Joel G. Breman

 

205
Leishmaniasis

Barbara L. Herwaldt

 

206
Trypanosomiasis

Louis V. Kirchhoff

 

207
Toxoplasma Infections

Lloyd H. Kasper

 

208
Protozoal Intestinal Infections and Trichomoniasis

Peter F. Weller


 

Section 19
 

Helminthic Infections

 

209
Trichinella and Other Tissue Nematodes

Peter F. Weller

 

210
Intestinal Nematodes

Peter F. Weller /Thomas B. Nutman

 

211
Filarial and Related Infections

Peter F. Weller / Thomas B. Nutman

 

212
Schistosomiasis and Other Trematode Infections

Adel A.F. Mahmoud

 

213
Cestodes

A. Clinton White, Jr. / Peter F. Weller


 

Part 8
 

Bioterrorism and Clinical Medicine

 

214
Microbioterrorism

H. Clifford Lane / Anthony S. Fauci

 

215
Chemical Bioterrorism

Charles G. Hurst / Jonathan Newmark / James A. Romano

 

216
Radiation Bioterrorism

Zelig A. Tochner / Eli Glatstein



 

Part 9
 

Disorders of Cardiovascular System



 

Section 1
 

Introduction to Cardiovascular Disorders

 

217
Basic Biology of the Cardiovascular System

Joseph Loscalzo / Peter Libby / Eugene Braunwald

 

218
Epidemiology of Cardiovascular Disease

Thomas A. Gaziano / J. Michael Gaziano

 

219
Approach to the Patient with Possible Cardiovascular Disease

Eugene Braunwald


 

Section 2
 

Diagnosis of Cardiovascular Disorders

 

220
Physical Examination of the Cardiovascular System

Robert A. O’Rourke /Eugene Braunwald

 

221
Electrocardiography

Ary L. Goldberger

 

e19
Atlas of Electrocardiography

Ary L. Goldberger

 

222
Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging

Rick Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik

 

e20
Atlas of Noninvasive Cardiac Imaging

Rick Nishimura

 

223
Diagnostic Cardiac Catheterization and Angiography

Donald S. Baim


 

Section 3
 

Disorders of Rhythm

 

224
Principles of Electrophysiology

Gordon F. Tomaselli

 

225
The Bradyarrhythmias

Gordon F. Tomaselli

 

226
The Tachyarrhythmias

Francis Marchlinksi

 

e21
Atlas of Cardiac Arrhythmias

Ary L. Goldberger

 

Section 4
 

Disorders of the Heart

 

227
Heart Failure and Cor Pulmonale

Douglas L. Mann

 

228
Cardiac Transplantation and Prolonged Assisted Circulation

Sharon A. Hunt

 

229
Congenital Heart Disease in the Adult

John S. Child

 

230
Valvular Heart Disease

Patrick O’Gara / Eugene Braunwald

 

231
Cardiomyopathy and Myocarditis

Joshua Wynne / Eugene Braunwald

 

232
Pericardial Disease

Eugene Braunwald

 

233
Tumors and Trauma of the Heart

Eric H. Awtry / Wilson S. Colucci

 

234
Cardiac Manifestations of Systemic Disease

Eric H. Awtry / Wilson S. Colucci


 

Section 5
 

Vascular Disease

 

235
The Pathogenesis, Prevention, and Treatment of Atherosclerosis

Peter Libby

 

e22
Atlas of Atherosclerosis

Peter Libby

 

236
The Metabolic Syndrome

Robert H. Eckel

 

237
Ischemic Heart Disease

Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo

 

238
Unstable Angina and Non-ST-Elevation Myocardial Infarction

Christopher P. Cannon / Eugene Braunwald

 

239
ST-Segment Elevation Myocardial Infarction

Elliott M. Antman / Eugene Braunwald

 

240
Percutaneous Coronary Intervention

Donald S. Baim

 

e23
Atlas of Percutaneous Revascularization

Donald S. Baim

 

241
Hypertensive Vascular Disease

Ted A. Kotchen

 

242
Diseases of the Aorta

Mark A. Creager / Joseph Loscalzo

 

243
Vascular Diseases of the Extremities

Mark A. Creager / Joseph Loscalzo

 

244
Pulmonary Hypertension

Stuart Rich


 

Part 10
 

Disorders of the Respiratory System

 

Section 1
 

Diagnosis of Respiratory Disorders

 

245
Approach to the Patient with Disease of the Respiratory System

David A. Lipson / Steven E. Weinberger

 

246
Disturbances of Respiratory Function

Steven E. Weinberger /Ilene M. Rosen

 

247
Diagnostic Procedures in Respiratory Diseases

Scott Manaker / Steven E. Weinberger

 

e24
Atlas of Chest Imaging

Patricia Kritek / John J. Reilly, Jr.

 

Section 2
 

Diseases of the Respiratory System

 

248
Asthma

Peter J. Barnes

 

249
Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia

Joel N. Kline / Gary W. Hunninghake

 

250
Environmental Lung Disease

Frank E. Speizer / John R. Balmes

 

251
Pneumonia

Lionel A. Mandell / Richard Wunderink

 

252
Bronchiectasis and Lung Abscess

Gregory Tino / Steven E. Weinberger

 

253
Cystic Fibrosis

Richard C. Boucher

 

254
Chronic Obstructive Pulmonary Disease

John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro

 

255
Interstitial Lung Diseases

Talmadge E. King, Jr.

 

256
Deep Venous Thrombosis and Pulmonary Thromboembolism

Samuel Z. Goldhaber

 

257
Disorders of the Pleura and Mediastinum

Richard W. Light

 

258
Disorders of Ventilation

Eliot A. Phillipson


 

259
Sleep Apnea

Neil J. Douglas

 

260
Lung Transplantation

Elbert P. Trulock


 

Part 11
 

Critical Care Medicine


 

Section 1
 

Respiratory Critical Care


 

261
Principles of Critical Care Medicine

John P. Kress / Jesse B. Hall

 

262
Acute Respiratory Distress Syndrome

Bruce D. Levy / Steve D. Shapiro

 

263
Mechanical Ventilatory Support

Edward P. Ingenito


 

Section 2
 

Shock and Cardiac Arrest


 

264
Approach to the Patient with Shock

Ronald V. Maier

 

265
Severe Sepsis and Septic Shock

Robert S. Munford

 

266
Cardiogenic Shock and Pulmonary Edema

Judith S. Hochman / David H. Ingbar

 

267
Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death

Robert J. Myerberg / Agustin Castellanos


 

Section 3
 

Neurologic Critical Care


 

268
Coma

Allan H. Ropper

 

269
Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage

J. Claude Hemphill / Wade S. Smith


 

Section 4
 

Oncologic Emergencies

 

270
Oncologic Emergencies

Rasim Gucalp / Janice Dutcher


 

Part 12
 

Disorders of the Kidney and Urinary Tract


 

271
Cellular and Molecular Biology of the Kidney

Alfred L. George / Eric G. Neilson

 

272
Adaptation of the Kidney to Renal Injury

Raymond C. Harris / Eric G. Neilson

 

273
Acute Renal Failure

Kathleen D. Liu / Glenn M. Chertow

 

274
Chronic Kidney Disease

Joanne M. Bargman / Karl Skorecki

 

275
Dialysis in the Treatment of Renal Failure

Kathleen D. Liu / Glenn M. Chertow

 

276
Transplantation in the Treatment of Renal Failure

Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh

 

277
Glomerular Diseases

Julia B. Lewis / Eric G. Neilson

 

278
Polycystic Kidney Disease and Other Inherited Tubular Disorders

David J. Salant / Parul S. Patel

 

279
Tubulointerstitial Diseases of the Kidney

Alan S. L. Yu / Barry M. Brenner

 

280
Vascular Injury to the Kidney

Kamal F. Badr / Barry M. Brenner

 

281
Nephrolithiasis

John R. Asplin / Fredric L. Coe / Murray J. Favus

 

282
Urinary Tract Infections, Pyelonephritis, and Prostatitis

Walter E. Stamm

 

283
Urinary Tract Obstruction

Julian L. Seifter / Barry M. Brenner


 

Part 13
 

Disorders of the Gastrointestinal System

 

Section 1
 

Disorders of the Alimentary Tract

 

284
Approach to the Patient with Gastrointestinal Disease

William L. Hasler / Chung Owyang

 

285
Gastrointestinal Endoscopy

Louis Michel Wong Kee Song / Mark Topazian


 

e25
Video Atlas of Gastrointestinal Endoscopy

Mark Topazian

 

286
Diseases of the Esophagus

Raj. K. Goyal

 

287
Peptic Ulcer Disease and Related Disorders

John Del Valle

 

288
Disorders of Absorption

Henry J. Binder

 

289
Inflammatory Bowel Disease

Sonia Friedman / Richard S. Blumberg

 

290
Irritable Bowel Syndrome

Chung Owyang

 

291
Diverticular Disease and Common Anorectal Disorders

Susan L. Gearhart

 

292
Mesenteric Vascular Insufficiency

Susan L. Gearhart

 

293
Acute Intestinal Obstruction

Susan L. Gearhart / William Silen

 

294
Acute Appendicitis and Peritonitis

Susan L. Gearhart / William Silen


 

Section 2
 

Liver and Biliary Tract Disease


 

295
Approach to the Patient with Liver Disease

Marc Ghany /Jay H. Hoofnagle

 

296
Evaluation of Liver Function

Daniel S. Pratt / Marshall M. Kaplan

 

297
The Hyperbilirubinemias

Allan W. Wolkoff

 

298
Acute Viral Hepatitis

Jules L. Dienstag

 

299
Toxic and Drug-Induced Hepatitis

Jules L. Dienstag

 

300
Chronic Hepatitis

Jules L. Dienstag

 

301
Alcoholic Liver Disease

Mark E. Malliard / Michael F. Sorrell

 

302
Cirrhosis and Its Complications

Bruce R. Bacon

 

e26
Atlas of Liver Biopsies

Jules L. Dienstag / Atul K. Bhau

 

303
Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver

Bruce R. Bacon

 

304
Liver Transplantation

Jules L. Dienstag /Raymond T. Chung

 

305
Diseases of the Gallbladder and Bile Ducts

Norton J. Greenberger / Gustav Paumgartner


 

Section 3
 

Disorders of the Pancreas


 

306
Approach to the Patient with Pancreatic Disease

Phillip P. Toskes / Norton J. Greenberger

 

307
Acute and Chronic Pancreatitis

Norton J. Greenberger / Phillip P. Toskes


 

Part 14
 

Disorders of the Immune System, Connective Tissue, and Joints

 

Section 1
 

The Immune System in Health and Disease

 

308
Introduction to the Immune System

Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci

 

309
The Major Histocompatability Complex

Gerald T. Nepom

 

310
Primary Immune Deficiency Diseases

Max D. Cooper / Harry W. Schroeder, Jr.

 

e27
Primary Immunodeficiencies Associated with or Secondary to Other Diseases

Max D. Cooper

 

Section 2
 

Disorders of Immune-Mediated Injury

 

311
Allergies, Anaphylaxis, and Systemic Mastocytosis

K. Frank Austen

 

312
Autoimmunity and Autoimmune Diseases

Peter E. Lipsky / Betty Diamond

 

313
Systemic Lupus Erythematosus

Bevra Hannahs Hahn

 

314
Rheumatoid Arthritis

Peter E. Lipsky

 

315
Acute Rheumatoid Fever

Jonathan R. Carapetis

 

316
Systemic Sclerosis (Scleroderma) and Related Disorders

John Varga

 

317
Sjögren’s Syndrome

Haralampos M. Moutsopoulos

 

318
The Spondyloarthritides

Joel D. Taurog

 

319
The Vasculitis Syndromes

Carol A. Langford / Anthony S. Fauci

 

e28
Atlas of Clinical Imaging of the Vasculitic Diseases

Carol A. Langford / Anthony S. Fauci

 

320
Behçet’s Syndrome

Haralampos M. Moutsopoulos

 

321
Relapsing Polychondritis

Carol A. Langford /Bruce C. Gilliland

 

322
Sarcoidosis

Robert P. Baughman /Elyse E. Lower

 

323
Familial Mediterranean Fever and Other Hereditary Recurrent Fevers

Daniel L. Kastner

 

324
Amyloidosis

David C. Seldin / Martha Skinner


 

Section 3
 

Disorders of the Joints and Adjacent Tissues

 

325
Approach to Articular and Musculoskeletal Disorders

John J. Cush / Peter E. Lipsky

 

326
Osteoarthritis

David T. Felson

 

327
Gout and Other Crystal Arthropathies

H. Ralph Schumacher / Lan X. Chen

 

328
Infectious Arthritis

Lawrence C. Madoff

 

329
Fibromyalgia

Carol A. Langford /Bruce C. Gilliland

 

330
Arthritis Associated with Systemic Disease and Other Arthritides

Carol A. Langford / Bruce C. Gilliland

 

331
Periarticular Disorders of the Extremities

Carol A. Langford / Bruce C. Gilliland


 

Part 15
 

Endocrinology and Metabolism

 

Section 1
 

Endocrinology


 

332
Principles of Endocrinology

J. Larry Jameson

 

333
Disorders of the Anterior Pituitary and Hypothalamus

Shlomo Melmed / J. Larry Jameson

 

334
Disorders of the Neurohypophysis

Gary L. Robertson

 

335
Disorders of the Thyroid Gland

J. Larry Jameson / Anthony P. Weetman
 

336
Disorders of the Adrenal Cortex

Gordon H. Williams / Robert G. Dluhy

 

337
Pheochromocytoma

Hartmut P.H. Neumann

 

338
Diabetes Mellitus

Alvin C. Powers

 

339
Hypoglycemia

Phillip E. Cryer

 

340
Disorders of the Testes and the Male Reproductive System

Shalender Bhasin / J. Larry Jameson

 

341
Disorders of the Ovary and Female Reproductive Tract

Janet E. Hall

 

342
The Menopause Transition and Postmenopausal Hormone Therapy

JoAnn E. Manson /Shari S. Bassuk

 

343
Disorders of Sex Development

John C. Achermann / J. Larry Jameson

 

344
Endocrine Tumors of the Gastrointestinal Tract and Pancreas

Robert T. Jensen

 

345
Disorders Affecting Multiple Endocrine Neoplasia Syndromes

Camillo Jimenez / Robert Gagel

 

Section 2
 

Disorders of Bone and Mineral Metabolism

346
Bone and Mineral Metabolism in Health and Disease

F. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg

 

347
Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemia Disorders

John T. Potts, Jr.
 

348
Osteoporosis

Robert Lindsay / Felicia Cosman

 

349
Paget Disease and Other Dysplasias of Bone

Murray J. Favus /Tamara J. Vokes

 

Section 3
 

Disorders of Intermediary Metabolism

 

350
Disorders of Lipoprotein Metabolism

Daniel J. Rader / Helen H. Hobbs


 

351
Hemochromatosis

Lawrie W. Powell

 

352
The Porphyrias

Robert J. Desnik / Kenneth H. Astrin


 

353
Disorders of Purine and Pyrimidine Metabolism

Robert L. Wortmann

 

354
Wilson Disease

George J. Brewer

 

355
Lysosomal Storage Disease
Robert J. Hopkin / Gregory A. Grabowski

 

356
Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism

Yuan-Tsong Chen

 

357
Heritable Disorders of Connective Tissue

Darwin J. Prockop / Malwina Czarny-Ratajczak

 

358
Inherited Disoders of Amino Acid Metabolism in Adults

Nicola Longo

 

359
Inherited Defects of Membrane Transport

Nicola Longo

 

e29
Atlas of Clinical Manifestations of Metabolic Diseases

J. Larry Jameson


 

Part 16
 

Neurologic Disorders

 

Section 1
 

Diagnosis of Neurologic Disorders

 

360
Mechanisms of Neurologic Disorders

Stephen Hauser / M. Flint Beal

 

361
Approach to the Patient with Neurologic Disease

Daniel H. Lowenstein / Joseph B. Martin / Stephen L. Hauser

 

362
Neuroimaging in Neurologic Disorders

William P. Dillon

 

e30
Atlas of Neuroimaging

Andre Furtado / William P. Dillon

 

e31
Electrodiagnostic Studies of Nervous System Disorders: EEG and EMG

Michael J. Aminoff

 

e32
Technique of Lumbar Puncture

Elizabeth Robbins / Stephen L. Hauser

 

Section 2
 

Diseases of the Central Nervous System



 

363
Seizures and Epilepsy

Daniel H. Lowenstein

 

364
Cerebrovascular Diseases

Wade S. Smith / Joey English / S. Claiborne Johnston

 

365
Dementia

Thomas D. Bird / Bruce L. Miller

 

366
Parkinson’s Disease and Other Extrapyramidal Disorders

Mahlon R. DeLong / Jorge L. Juncos


 

367
Hyperkinetic Movement Disorders

C. Warren Olanow

 

368
Ataxic Disorders

Roger N. Rosenberg

 

369
Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases

Robert H. Brown, Jr.

 

370
Disorders of the Autonomic Nervous System

Phillip A. Low / John W. Engstrom

 

371
Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders

M. Flint Beal / Stephen L. Hauser

 

372
Diseases of the Spinal Cord

Stephen L. Hauser / Allan H. Ropper

 

373
Concussion and Other Head Injuries

Allan H. Ropper

 

374
Primary and Metastatic Tumors of the Nervous System

Stephen M. Sagar / Mark A. Israel

 

375
Multiple Sclerosis and Other Demyelinating Diseases

Stephen L. Hauser / Douglas S. Goodin

 

376
Meningitis, Encephalitis, Brain Abscess,and Empyema

Karen L. Roos / Kenneth L. Tyler

 

377
Chronic and Recurrent Meningitis


Walter J. Koroshetz / Morton N. Swartz

 

378
Prion Diseases

Stanley B. Prusiner / Bruce L. Miller


 

Section 3
 

Nerve and Muscle Disorders

 

379
Peripheral Neuropathy

Vinay Chaudhry

 

380
Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies

Steven L. Hauser / Arthur K. Asbury

 

381
Mysathenia Gravis and Other Diseases of the Neuromuscular Junction

Daniel B. Drachman

 

382
An Approach to Muscular Dystrophy and Other Muscle Diseases

Robert H. Brown, Jr. / Anthony A. Amato / Jerry R. Mendell

 

383
Polymyositis, Dermatomyositis, and Inclusion Body Myositis

Marinos C. Dalakas

 

e33
Special Issues in Inpatient Neurologic Consultation

S. Andrew Josephson / Martin A. Samuels


 

Section 4
 

Chronic Fatigue Syndrome

 

384
Chronic Fatigue Syndrome

Stephen E. Straus


 

Section 5
 

Psychiatric Disorders

 

385
Biology of Psychiatric Disorders

Steve Hyman / Eric Kandel


 

386
Mental Disoders

Victor I. Reus


 

Section 6
 

Alcoholism and Drug Dependency


 

387
Alcohol and Alcoholism

Marc A. Schuckit

 

388
Opioid Drug Abuse and Dependence

Mark A. Schuckit

 

389
Cocaine and Other Commonly Abused Drugs

Jack H. Medelson / Nancy K. Mello

 

390
Nicotine Addiction

David M. Burns


 

Part 17
 

Poisoning, Drug Overdose, and Envenomation


 

e34
Heavy Metal Poisoning

Howard Hu

 

e35
Poisoning and Drug Overdosage

Christopher H. Linden / Michael J. Burns / Mark B. Mycyk


 

391
Disorders Caused by Reptile Bites and Marine Animal Exposures

Paul Auerbach / Robert Norris

 

e36
Ectoparasite Infestations and Arthropod Bites and Stings

Richard J. Pollack / James H. Maguire

 

International e Chapters

 

e37
Pulmonary Biomarkers in COPD

Peter J. Barnes
 

e38
Chagas’ Disease: Recent Advances in Diagnosis and Management

Andrei C. Sposito / Jose A.F. Ramires

Summaries of Chapters e1 to e36

Appendix
 

Laboratory Values of Clinical Importance


Alexander Kratz / Michael A. Pesce / Daniel J. Fink
 

Index