Table of Contents: 

Part I:  Delivery Systems and Therapeutic Strategies

Chapter 1.     Retroviral Vectors for Gene Therapy

Chapter 2.     Adenovirus Vectors for Gene Therapy

Chapter 3.     Modified Adenoviruses for Gene Therapy

Chapter 4.     Helper-dependent Adenoviral Vectors for Gene Therapy

Chapter 5.     Adeno-associated Virus and AAV Vectors for Gene Delivery

Chapter 6.     Engineering Herpes Simplex Viral Vectors for Therapeutic Gene Transfer

Chapter 7.     Lentiviral Vectors

Chapter 8.     Ex Vivo Gene Therapy Using Myoblasts and Regulatable Retroviral Vectors

Chapter 9.     Vaccinia Viral Vectors

Chapter 10.    Baculovirus-mediated Gene Transfer:  An Evolving New Concept

Chapter 11.    Bacteria as Vectors for Gene Therapy of Cancer

Chapter 12.    Polyfunctional Vectors for Gene Delivery

Chapter 13.    Receptor-Targeted Polyplexes

Chapter 14.    Electrokinetic Enhancement of Plasmid Delivery In Vivo

Chapter 15.    Gene Gun Technologies:  Applications for Gene Therapy and Genetic Immunization

Chapter 16.    Optimization of Nonviral Gene Therapeutics

Chapter 17.    Molecular Interactions in Lipids, DNA, and DNA-Lipid Complexes

Part II:  Other Therapeutic Strategies   

Chapter 18.    Gene Therapy Applications of Ribozymes

Chapter 19.    Antisense Oligonucleotide-based Therapeutics

Chapter 20.    Suicide Gene Therapy

Chapter 21.    Selectable Markers for Gene Therapy

Part III:  Gene Expression and Detection

Chapter 22.    Lipid-dependent Transcription Switches and Their Potential for Gene Therapy

Chapter 23.    Monitoring Gene Therapy in Living Subjects with Molecular Imaging Technologies

Part IV:  Disease Targets and Therapeutic Strategies

Chapter 24.    Gene Transfer into Hematopoietic Stem Cells

Chapter 25.    Gene Therapy for Hematopoietic Disorders

Chapter 26.    Gene Therapy for Cardiovascular Disease and Vascular Grafts

Chapter 27.    Gene Therapy for Cancer

Chapter 28.    Overcoming Barriers to Efficient Airway Epithelial Gene Transfer

Chapter 29.    Gene Therapy for Neurological Diseases

Chapter 30.    Principles of Gene Therapy for Inborn Errors of Metabolism

Chapter 31.    Gene Therapy and HIV-1 Infection

Chapter 32.    Cutaneous Gene Therapy for Skin and Systemic Disorders

Chapter 33.    Gene Therapy for Childhood Onset Blindness

Chapter 34.    DNA Vaccines

Part V:  Gene Therapy Clinical Trials and Regulatory Issues

Chapter 35.    Cardiovascular Gene Therapy

Chapter 36.    Selectively Replicating Adenoviruses:  Clinical Experience with Onyx015 and Future Directions

Chapter 37.    Gene Therapy for the Treatment of Cancer:  From Laboratory to Bedside

Chapter 38.    Gene Therapy Clinical Trials for Cancer:  Replacement of Tumor Suppressor Gene p53

Chapter 39.    Ex Vivo Gene Therapy for Alzheimer's Disease

Chapter 40.    Prospects for Clinical Applications of Synthetic Gene Delivery Vectors

Chapter 41.    Regulatory Aspects of Gene Therapy

Part VI:  Other Cell-Based Therapies and Trials

Chapter 42.    Immuoisolated Cells as Gene Therapy for CNS Diseases

Chapter 43.    Hematopoietic Progenitor Cells

Chapter 44.    Gene Marking Studies of Hematopoietic Cells

Chapter 45.    Gene-Based Vaccination Against Malignant Melanoma