Table of Contents:

VOLUME 1:

Part I:  Genetics and Embryology

Chapter 1.     Basic Genetic Principles

Chapter 2.     Molecular Genetics:  Developmental and Clinical Implications

Chapter 3.     Basic Embryology

Chapter 4.     Regulation of Embryogenesis

Chapter 5.     The Extracellular Matrix in Development

Chapter 6.     Stem Cell Biology

Chapter 7.     Homeobox Genes

Chapter 8.     Apoptosis and Necrosis

Chapter 9.     Angiogenesis    

Part II:  Placenta and Intrauterine Environment

Chapter 10.   Placental Development

Chapter 11.   Regulation of Placental Circulation

Chapter 12.   Pathophysiology of Preterm Birth

Chapter 13.   Mechanisms of Transfer Across the Human Placenta

Chapter 14.   Endocrine and Paracrine Function of the Human Placenta

Chapter 15.   Fetal and Maternal Responses to Intrauterine Infection

Chapter 16.   Maternal Cardiovascular Disease and Fetal Growth

Chapter 17.   Fetal Origins of Adult Disease

Chapter 18.   Physiologic Effects of Multiple Pregnancy on Mother and Fetus

Part III:  Developmental Pharmacology and Pharmacokinetics

Chapter 19.   Basic Pharmacologic Principles

Chapter 20.   Basic Pharmacokinetic Principles

Chapter 21.   Physicochemical and Structural Properties Regulating Placental Drug Transfer

Chapter 22.   Pharmacogenetics

Chapter 23.   Drug Distribution in Fetal Life

Chapter 24.   Developmental Pharmacology of Adrenergic Agents

Chapter 25.   Maternal Drug Abuse:  Effects on Fetus and Neonate

Chapter 26.   Drug Excretion During Lactation

Part IV:  Intrauterine and Postnatal Growth

Chapter 27.   Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction

Chapter 28.   Endocrine Factors Affecting Neonatal Growth

Chapter 29.   Human Milk Composition and Function in the Infant

Chapter 30.   Physiology of Lactation

Chapter 31.   Nutritional Assessment

Part V:  Perinatal Iron, Mineral, and Vitamin Metabolism

Chapter 32.   Calcium-Regulating Hormones

Chapter 33.   Calcium, Phosphorus, and Magnesium Transport Across the Placenta

Chapter 34.   Neonatal Calcium, Phosphorus, and Magnesium Homeostasis

Chapter 35.   Zinc in the Fetus and Neonate

Chapter 36.   Vitamin A Metabolism in the Fetus and Neonate

Chapter 37.   Vitamin E Nutrition in the Fetus and Newborn

Chapter 38.   Vitamin K Metabolism in the Fetus and Neonate

 Part VI:  Lipid Metabolism

Chapter 39.   Maternal-Fetal Transfer of Lipid Metabolites

Chapter 40.   Accretion of Lipid in the Fetus and Newborn

Chapter 41.   Brown Adipose Tissue:  Development and Function

Chapter 42.   Lipids as an Energy Source for the Premature and Full-Term Neonate

Chapter 43.   Ketone Body Production and Metabolism in the Fetus and Neonate

Chapter 44.   Long Chain Fatty Acids in the Developing Retina and Brain

Chapter 45.   Lipoprotein Metabolism and Nutritional Programming in the Fetus and Neonate

Part VII:  Carbohydrate Metabolism

Chapter 46.   Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn

Chapter 47.   Carbohydrate Metabolism During Pregnancy

Chapter 48.   Oxygen Consumption and General Carbohydrate Metabolism in the Fetus

Chapter 49.   Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period

Chapter 50.   Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development

Chapter 51.   Pathophysiology of Hypoglycemia

Part VIII:  Protein Metabolism

Chapter 52.   General Concepts of Protein Metabolism

Chapter 53.   Fetal Requirements and Placental Transfer of Nitrogenous Compounds

Chapter 54.   Protein and Amino Acid Metabolism and Requirements

Part IX:  Thermoregulation

Chapter 55.   Perinatal Thermal Physiology

Chapter 56.   Temperature Control in Newborn Infants

Chapter 57.   Physics and Physiology of Human Neonatal Incubation

Chapter 58.   Responses of the Fetus and Neonate to Hypothermia

Part X:  Skin

Chapter 59.   Structure and Development of the Skin and Cutaneous Appendages

Chapter 60.   Physiologic Development of the Skin

Part XI:  Fetal and Neonatal Cardiovascular Physiology

Chapter 61.   Development of the Fetal Heart

Chapter 62.   Molecular Determinants of Embryonic Vascular Development

Chapter 63.   Cardiovascular Function During Development and the Response to Hypoxia

Chapter 64.   Developmental Electrophysiology in the Fetus and Neonate

Chapter 65.   Developmental Biology of the Pulmonary Vasculature

Chapter 66.   Development of the Gastrointestinal Circulation in the Fetus and Newborn

Chapter 67.   Physiology of Congenital Heart Disease in the Neonate

Chapter 68.   Neural Regulation of Blood Pressure During Fetal and Newborn Life

Chapter 69.   Programming of the Fetal Circulation

Chapter 70.   Physiology of Nitric Oxide in the Developing Lung

Chapter 71.   Mechanisms Regulating Closure of the Ductus Arteriosus

Chapter 72.   Regulation of Umbilical Blood Flow

Chapter 73.   Fetal and Placental Circulation During Labor

Chapter 74.   Physiology of Resuscitation

Chapter 75.   Pathophysiology of Shock in the Fetus and Neonate

Part XII:  The Lung

Chapter 76.   Normal and Abnormal Structural Development of the Lung

Chapter 77.   Regulation of Alveolarization

Chapter 78.   Physiologic Mechanisms of Normal and Altered Lung Growth

Chapter 79.   Molecular Mehanisms of Lung Development and Lung Branching Morphogenesis

Chapter 80.   Regulation of Liquid Secretion and Absorption

Chapter 81.   Upper Airway Structure:  Funciton, Regulation, and Development

Chapter 82.   Regulation of Lower Airway Function

Chapter 83.   Functional Developmental of Respiratory Muscles

Chapter 84.   Mechanics of Breathing

Chapter 85.   Pulmonary Gas Exchange in the Developing Lung

Chapter 86.   Oxygen Transport and Delivery

Chapter 87.   Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate

Chapter 88.   Basic Mechanisms of Oxygen-Sensing and Response to Hypoxia

Chapter 89.   Pathophysiology of Apnea of Prematurity

Chapter 90.   Evaluation of Pulmonary Function in the Neonate

Chapter 91.   Pathophysiology of Hyaline Membrane Disease (Excluding Surfactant)

Chapter 92.   Mechanisms of Neonatal Lung Injury

Chapter 93.   Impaired Lung Growth After Injury in Premature Lung

Chapter 94.   Antenatal Factors That Influence Postnatal Lung Development and Injury

Chapter 95.   Pathophysiology of Chronic Lung Disease

Chapter 96.   Assisted Ventilation:  Physiologic Implications and Complications

Chapter 97.   High-Frequency Ventilation

Chapter 98.   Liquid Ventilation

VOLUME 2:

Part XIII:  Surfactant

Chapter 99.   Historical Perspective

Chapter 100.  Composition of Pulmonary Surfactant Lipids and Proteins

Chapter 101.  Physicochemical Aspects of Pulmonary Surfactant

Chapter 102.  Structure of Alveolar Epithelial Cells and the Surface Layer During Development

Chapter 103.  Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion

Chapter 104.  Pathophysiology of Respiratory Distress Syndrome and Surfactant Metabolism

Chapter 105.  Hormonal Therapy for Prevention of Respiratory Distress Syndrome

Chapter 106.  Surfactant Treatment

Chapter 107.  Genetics and Physiology of Surfactant Protein Deficiencies

Part XIV:  Physiology of the Gastrointestinal Tract in the Fetus and Neonate

Chapter 108.  Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development

Chapter 109.  Organogenesis of the Gastrointestinal Tract

Chapter 110.  Development of the Enteric Nervous System

Chapter 111.  Development of Gastric Secretory Function

Chapter 112.  Gastrointestinal Motility

Chapter 113.  Fetal and Neonatal Intestinal Motility

Chapter 114.  Development of the Exocrine Pancreas

Chapter 115.  Digestion-Absorption Functions in Fetuses, Infants, and Children

Chapter 116.  Pathophysiology of Gastroesophogeal Reflux

Chapter 117.  Pathophysiology and Prevention of Neonatal Necrotizing Enterocolitis

Part XV:  Liver and Bilirubin Metabolism

Chapter 118.  Organogenesis and Histologic Development of the Liver

Chapter 119.  Bile Acid Metabolism During Development

Chapter 120.  Bile Formation and Cholestasis

Chapter 121.  Bilirubin Metabolism and Toxicity in the Newborn

Chapter 122.  Mechanisms of Action of Phototherapy

Chapter 123.  Pathophysiology of Metabolic Disease of the Liver

Chapter 124.  Neonatal Cholestasis:  Pathophysiology, Etiology, and Treatment

Part XVI:  The Kidney

Chapter 125.  Embryogenesis and Anatomic Development

Chapter 126.  Functional Development of the Kidney In Utero

Chapter 127.  Postnatal Maturation of Renal Blood Flow

Chapter 128.  Development of the Renin-Angiotensin System

Chapter 129.  Postnatal Development of GlomerularFiltration

Chapter 130.  Renal Transport of Sodium During Early Development

Chapter 131.  Potassium Homeostasis in the Fetus and Neonate

Chapter 132.  Role of the Kidney in Calcium and Phosphorus Homeostasis

Chapter 133.  Transport of Amino Acids During Early Development

Chapter 134.  Developmental Aspects of Organic Acid Transport

Chapter 135.  Concentration and Dilution of the Urine

Chapter 136.  Urinary Acidification

Chapter 137.  Response to Nephron Loss in Early Development

Chapter 138.  Pathophysiology of Acute Renal Failure in the Neonatal Period

Part XVII:  Fluid and Electrolyte Metabolism

Chapter 139.  Fluid Distribution in the Fetus and Neonate

Chapter 140.  Fetal and Neonatal Body Water Compartment Volumes with Reference to Growth and Development

Chapter 141.  Pathophysiology of Edema

Chapter 142.  Regulation of Acid-Base Balance in the Fetus and Neonate

Part XVIII:  Developmental Hematopoiesis

Chapter 143.  Biology of Stem Cells and Stem Cell Transplantation

Chapter 144.  Developmental Biology of the Hematopoietic Growth Factors

Chapter 145.  Developmental Granulocytopoiesis

Chapter 146.  Developmental Erythropoeisis

Chapter 147.  Developmental Megakaryocytopoiesis in Fetal and Neonatal Physiology

Part XIX:  Hemostasis

Chapter 148.  Developmental Hemostasis

Chapter 149.  Pathophysiology of Bleeding Disorders in the Newborn

Chapter 150.  Pathophysiology of Neonatal Disseminated Intravascular Coagulation and Thrombosis

Part XX:  Developmental Immunobiology

Chapter 151.  Host Defense Mechanisms Against Bacteria

Chapter 152.  Host Defense Mechanisms Against Fungi

Chapter 153.  Host Defense Mechanisms Against Viruses

Chapter 154.  T-Cell Development

Chapter 155.  B-Cell Development

Chapter 156.  Mononuclear Phagocyte System

Chapter 157.  Neonatal Neutrophil Normal and Abnormal Physiology

Chapter 158.  The Complement System of the Fetus and Neonate

Chapter 159.  Cytokines and Inflammatory Response in the Fetus and Neonate

Chapter 160. Integrins and Cell Adhesion Molecules

Chapter 161.  Stimulus-Response Coupling in Phagocytic Cells

Chapter 162.  Fetal Wound Healing

Chapter 163.  Immunology of Human Milk and Host Immunity

Chapter 164.  Neonatal Pulmonary Host Defense Mechanisms

Part XXI:  Neurology

Chaper 165.  Development of the Nervous System

Chapter 166.  Development of the Blood-Brain Barrier

Chapter 167.  Development of Neurotransmitters

Chapter 168.  Perinatal Brain Metabolism

Chapter 169.  Electroencephalography in the Premature and Full-Term Infant

Chapter 170.  Cerebral Blood Flow in Premature Infants:  Regulation, Measurement, and Pathophysiology of Intraventricular Hemorrhage

Chapter 171.  Pathophysiology of Intraventricular Hemorrhage in the Neonate

Chapter 172.  Pathophysiology of Neural Tube Defects

Chapter 173.  Trophic Factors and Nutritional and Hormonal Regulation of Brain Development

Chapter 174.  Development of Pain Sensation

Part XXII:  Special Sensory Systems in the Fetus and Neonate

Chapter 175.  Retinal Development and the Pathophysiology of Retinopathy of Prematurity

Chapter 176.  Early Development of the Human Auditory System

Chapter 177.  Development of Taste and Smell in the Neonate

Part XXIII:  Orthopedics

Chapter 178.  The Growth Plate:  Embryologic Origin, Structure, and Function

Chapter 179.  Common Musculoskeletal Conditions Related to Intrauterine Compression:  Effects of Mechanics on Endochondral Ossification

Chapter 180.  Defective Limb Embryology

Chapter 181.  Ontogenesis of Striated Muscle

Part XXIV:  Endocrine Function

Chapter 182.  Hypothalamus:  Neuroendometabolic Center

Chapter 183.  Growth Factor Regulation of Fetal Growth

Chapter 184.  Growth Hormone and Prolactin

Chapter 185.  Luteinizing Hormone and Follicle-Stimulating Hormome Secretion in the Fetus and Newborn Infant

Chapter 186.  Development of the Corticotropin-Releasing Hormone-Corticotropin/β-Endorphin System in the Mammalian Fetus

Chapter 187.  Fetal and Neonatal Adrenocortical Physiology

Chapter 188.  Fetal and Neonatal Thyroid Physiology

Part XXV:  Ovary and Testis

Chapter 189.  Genetics of Sex Determination and Differentiation

Chapter 190.  Differentiation of the Ovary

Chapter 191.  Testicular Development

Chapter 192.  Testicular Descent