Table of Contents:

Chapter 1.     Introduction

Part I:  Scientific Foundations

Chapter 2.     Pathophysiology of Seizures and Epilepsy

Chapter 3.     Drug Resistance in Epilepsy and Status Epilepticus

Chapter 4.     Genetics of Human Epilepsy-Epilepsy as a Channelopathy

Part II:  Antiepileptic Drugs

Chapter 5.     Ontogeny of Molecular Targets of Antiepileptic Drugs:  Impact on Drug Choice

Chapter 6.     Epilepsy and Disease Modification:  Animal Models for Novel Drug Discovery

Chapter 7.     Nonsynaptic Mechanisms in Seizures and Epileptogenesis:  Targets for Clinical Management?

Chapter 8.     A Mechanistic Approach to Antiepileptic Drug Interactions

Chapter 9.     Toxicology of Idiosyncratic Organ Toxicities of AEDs

Part III:  Epilepsy Surgery

Chapter 10.   Advances in Structural and Functional Neuroimaging:  How Are These Guiding Epilepsy Surgery?

Chapter 11.   Magnetoencephalography in Clinical Epilepsy

Chapter 12.   Nonsurgical Ablation of Epileptic Tissue

Part IV:  Alternative Therapies

Chapter 13.   Special Treatments in Epilepsy

Chapter 14.   The Ketogenic Diet:  Scientific Principles Underlying Its Use

Chapter 15.   Vagus Nerve Stimulation

Chapter 16.   Immunomodulation of Epilepsy

Chapter 17.   Neurosteroids:  Endogenous Modulators of Seizure Susceptibility

Part V:  Other Modulators of the Epileptic State

Chapter 18.   Impact of Neuroendocrine Factors on Seizure Genesis and Treatment

Chapter 19.   Chronobiology and Sleep:  Implications for Seizure Propensity

Chapter 20.   Psychopathology in Epilepsy:  A Window to Brain Behavior Relationships

Part VI:  The Future of Epilepsy Therapy

Chapter 21.   Novel Mechanisms of Drug Delivery

Chapter 22.   Deep Brain Stimulation:  Why Should This Work?

Chapter 23.   Intraoperative Optical Imaging of Epileptiform and Functional Activity

Chapter 24.   Early Seizure Detection:  Theoretical and Applied

Chapter 25.   Arresting Epileptogenesis:  The Current Challenge